AIMC Topic: Drug Delivery Systems
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Machine Learning-Driven Prediction, Preparation, and Evaluation of Functional Nanomedicines Via Drug-Drug Self-Assembly.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Jan 10, 2025
Small molecules as nanomedicine carriers offer advantages in drug loading and preparation. Selecting effective small molecules for stable nanomedicines is challenging. This study used artificial intelligence (AI) to screen drug combinations for self-...
Toward Resolving Heterogeneous Mixtures of Nanocarriers in Drug Delivery Systems through Light Scattering and Machine Learning.
ACS nano
Jan 8, 2025
Nanocarriers (NCs) have emerged as a revolutionary approach in targeted drug delivery, promising to enhance drug efficacy and reduce toxicity through precise targeting and controlled release mechanisms. Despite their potential, the clinical adoption ...
Intelligence analysis of drug nanoparticles delivery efficiency to cancer tumor sites using machine learning models.
Scientific reports
Jan 6, 2025
This study focuses on the use of machine learning (ML) models to predict the biodistribution of nanoparticles in various organs, using a dataset derived from research on nanoparticle behavior for cancer treatment. The dataset includes both categorica...
Preparation and optimisation of solid lipid nanoparticles of rivaroxaban using artificial neural networks and response surface method.
Journal of microencapsulation
Jan 5, 2025
AIMS: This study aimed to improve rivaroxaban delivery by optimising solid lipid nanoparticles (SLN) for minimal mean diameter and maximal entrapment efficiency (EE), enhancing solubility, bioavailability, and the ability to cross the blood-brain bar...
Deep Learning for the Accurate Prediction of Triggered Drug Delivery.
IEEE transactions on nanobioscience
Jan 2, 2025
The need to mitigate the adverse effects of chemotherapy has driven the exploration of innovative drug delivery approaches. One emerging trend in cancer treatment is the utilization of Drug Delivery Systems (DDSs), facilitated by nanotechnology. Nano...
Sub-millimeter fiberscopic robot with integrated maneuvering, imaging, and biomedical operation abilities.
Nature communications
Dec 30, 2024
Small-scale continuum robots hold promise for interventional diagnosis and treatment, yet existing models struggle to achieve small size, precise steering, and visualized functional treatment simultaneously, termed an "impossible trinity". This study...
Breaking Through Physiological Barriers: Nanorobotic Strategies for Active Drug Delivery.
Bioconjugate chemistry
Dec 27, 2024
Self-propelled micro/nanomotors (MNMs) represent a groundbreaking advancement in precision drug delivery, offering potential solutions to persistent challenges such as systemic toxicity, limited bioavailability, and nonspecific distribution. By trans...
Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management.
Drug design, development and therapy
Dec 19, 2024
PURPOSE: Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast ca...
Actuation-Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 18, 2024
Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and r...
Strategies for the design of biomimetic cell-penetrating peptides using AI-driven in silico tools for drug delivery.
Biomaterials advances
Dec 16, 2024
Cell-penetrating peptides (CPP) have gained rapid attention over the last 25 years; this is attributed to their versatility, customisation, and 'Trojan horse' delivery that evades the immune system. However, the current CPP rational design process is...
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