AIMC Topic: Drug Resistance, Multiple, Bacterial

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Selenazolinium Salts as "Small Molecule Catalysts" with High Potency against ESKAPE Bacterial Pathogens.

Molecules (Basel, Switzerland) Dec 8, 2017
In view of the pressing need to identify new antibacterial agents able to combat multidrug-resistant bacteria, we investigated a series of fused selenazolinium derivatives (-) regarding their in vitro antimicrobial activities against 25 ESKAPE-pathog...
Azoles Isoindoles Organoselenium Compounds Oxidative Stress Humans Bacteria Anti-Bacterial Agents Structure-Activity Relationship Microbial Sensitivity Tests Molecular Structure Drug Resistance, Multiple, Bacterial
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Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Pyrazoles Gram-Negative Bacteria Gram-Positive Bacteria Binding Sites Structure-Activity Relationship Catalytic Domain Acinetobacter baumannii Benzoic Acid Anti-Infective Agents Molecular Docking Simulation Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial
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Antimicrobial activity of ceftazidime-avibactam and comparator agents when tested against bacterial isolates causing infection in cancer patients (2013-2014).

Diagnostic microbiology and infectious disease Nov 29, 2016
We evaluated the antimicrobial susceptibility of 623 Gram-negative organisms causing infection in patients with cancer in 52 United States hospitals (2013-2014) as part of the International Network for Optimal Resistance Monitoring (INFORM) program. ...
Pseudomonas aeruginosa Meropenem Colistin Enterobacter cloacae Klebsiella pneumoniae Drug Combinations Escherichia coli beta-Lactamases Humans Amikacin Anti-Bacterial Agents Azabicyclo Compounds Neoplasms Ceftazidime Microbial Sensitivity Tests Thienamycins Drug Resistance, Multiple, Bacterial
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Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains.

Epidemiology and infection Aug 3, 2015
Multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections are major threats to healthcare-associated infection control and the intrinsic molecular mechanisms of MDRPA are also unclear. We examined 348 isolates of P. aeruginosa, including 188 MDRP...
Multifactor Dimensionality Reduction Bacterial Proteins Tertiary Care Centers Pseudomonas aeruginosa Pseudomonas Infections Anti-Bacterial Agents China Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial
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Characterization of fecal vancomycin-resistant enterococci with acquired and intrinsic resistance mechanisms in wild animals, Spain.

Microbial ecology Jul 21, 2015
The objectives were to evaluate the presence of vancomycin-resistant enterococci with acquired (VRE-a) and intrinsic (VRE-i) resistance mechanisms in fecal samples from different wild animals, and analyze their phenotypes and genotypes of antimicrobi...
Animals Animals, Wild Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Feces Bacterial Proteins Ampicillin Galliformes Vancomycin Tetracycline Tetracycline Resistance Ampicillin Resistance Vancomycin-Resistant Enterococci Multilocus Sequence Typing Carbon-Oxygen Ligases Spain Enterococcus faecium Aminoglycosides Falconiformes Sus scrofa
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Genomic and machine learning approaches to predict antimicrobial resistance in .

Microbiology spectrum Aug 5, 2025
UNLABELLED: is a multidrug-resistant pathogen, which poses a major challenge to clinical management due to its increasing resistance to common antibiotics, such as levofloxacin (LEV) and trimethoprim-sulfamethoxazole (SXT), and poor clinical respons...
Humans Genomics Bacterial Proteins Mutation Whole Genome Sequencing Machine Learning Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Stenotrophomonas maltophilia Gram-Negative Bacterial Infections Levofloxacin Genome, Bacterial Trimethoprim, Sulfamethoxazole Drug Combination
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Decoding virulence and resistance in Klebsiella pneumoniae: Pharmacological insights, immunological dynamics, and in silico therapeutic strategies.

Microbial pathogenesis Aug 1, 2025
Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the leading members of ESKAPE pathogens, it plays a major role in a wide range of infections that cause ...
Bacterial Vaccines Immune Evasion Computer Simulation Drug Discovery Drug Resistance, Multiple, Bacterial Klebsiella pneumoniae Klebsiella Infections Virulence Factors Virulence beta-Lactamases Humans Anti-Bacterial Agents Drug Resistance, Bacterial
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Novel robotic tools used for the detection of faecal shedding of Escherichia coli resistant to critically important antimicrobials in healthy dogs.

Veterinary microbiology Jul 1, 2025
Escherichia coli recovered from dogs with clinical conditions such as urinary tract infections are often used to assess populations for resistance to critically important antimicrobials (CIAs). Despite the potential importance of such strains, the nu...
Animals Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Feces Anti-Bacterial Agents Drug Resistance, Bacterial Dogs Escherichia coli Dog Diseases Robotics Fluoroquinolones Escherichia coli Infections Multilocus Sequence Typing Ciprofloxacin Bacterial Shedding
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Accelerating antimicrobial stewardship: An AI-CDSS approach to combating multidrug-resistant pathogens in the era of increasing resistance.

Clinica chimica acta; international journal of clinical chemistry Jun 15, 2025
OBJECTIVES: The World Health Organization has identified Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) as significant public health threats owing to high antibiotic resistance. Traditional antibiotic susceptibility testing (AST) methods,...
Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Decision Support Systems, Clinical Klebsiella pneumoniae Pseudomonas aeruginosa Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Antimicrobial Stewardship Humans Artificial Intelligence Machine Learning
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Evolutionary accumulation modeling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance.

mBio Jun 11, 2025
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of anti...
Bacteria Evolution, Molecular Mycobacterium tuberculosis Humans Machine Learning Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial
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