AIMC Topic: Drug Resistance, Multiple, Bacterial

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Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Gram-Positive Bacteria Binding Sites Anti-Infective Agents Acinetobacter baumannii Molecular Docking Simulation Benzoic Acid Microbial Sensitivity Tests Pyrazoles Drug Resistance, Multiple, Bacterial Gram-Negative Bacteria Structure-Activity Relationship Catalytic Domain
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Antimicrobial activity of ceftazidime-avibactam and comparator agents when tested against bacterial isolates causing infection in cancer patients (2013-2014).

Diagnostic microbiology and infectious disease Nov 29, 2016
We evaluated the antimicrobial susceptibility of 623 Gram-negative organisms causing infection in patients with cancer in 52 United States hospitals (2013-2014) as part of the International Network for Optimal Resistance Monitoring (INFORM) program. ...
Escherichia coli beta-Lactamases Pseudomonas aeruginosa Meropenem Humans Microbial Sensitivity Tests Anti-Bacterial Agents Ceftazidime Drug Resistance, Multiple, Bacterial Colistin Neoplasms Thienamycins Klebsiella pneumoniae Enterobacter cloacae Drug Combinations Amikacin Azabicyclo Compounds
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Application of the multifactor dimensionality reduction method in evaluation of the roles of multiple genes/enzymes in multidrug-resistant acquisition in Pseudomonas aeruginosa strains.

Epidemiology and infection Aug 3, 2015
Multidrug-resistant Pseudomonas aeruginosa (MDRPA) infections are major threats to healthcare-associated infection control and the intrinsic molecular mechanisms of MDRPA are also unclear. We examined 348 isolates of P. aeruginosa, including 188 MDRP...
Pseudomonas Infections Multifactor Dimensionality Reduction Drug Resistance, Multiple, Bacterial Bacterial Proteins Tertiary Care Centers Pseudomonas aeruginosa Anti-Bacterial Agents China Microbial Sensitivity Tests
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Characterization of fecal vancomycin-resistant enterococci with acquired and intrinsic resistance mechanisms in wild animals, Spain.

Microbial ecology Jul 21, 2015
The objectives were to evaluate the presence of vancomycin-resistant enterococci with acquired (VRE-a) and intrinsic (VRE-i) resistance mechanisms in fecal samples from different wild animals, and analyze their phenotypes and genotypes of antimicrobi...
Animals Animals, Wild Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Feces Bacterial Proteins Enterococcus faecium Falconiformes Galliformes Aminoglycosides Tetracycline Sus scrofa Ampicillin Tetracycline Resistance Ampicillin Resistance Vancomycin Vancomycin-Resistant Enterococci Carbon-Oxygen Ligases Multilocus Sequence Typing Spain
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Decoding virulence and resistance in Klebsiella pneumoniae: Pharmacological insights, immunological dynamics, and in silico therapeutic strategies.

Microbial pathogenesis Aug 1, 2025
Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the leading members of ESKAPE pathogens, it plays a major role in a wide range of infections that cause ...
Bacterial Vaccines Immune Evasion Computer Simulation Drug Discovery Drug Resistance, Multiple, Bacterial Klebsiella pneumoniae Klebsiella Infections Virulence Factors Virulence beta-Lactamases Humans Anti-Bacterial Agents Drug Resistance, Bacterial
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Novel robotic tools used for the detection of faecal shedding of Escherichia coli resistant to critically important antimicrobials in healthy dogs.

Veterinary microbiology Jul 1, 2025
Escherichia coli recovered from dogs with clinical conditions such as urinary tract infections are often used to assess populations for resistance to critically important antimicrobials (CIAs). Despite the potential importance of such strains, the nu...
Animals Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Feces Anti-Bacterial Agents Drug Resistance, Bacterial Dogs Dog Diseases Escherichia coli Fluoroquinolones Multilocus Sequence Typing Robotics Bacterial Shedding Escherichia coli Infections Ciprofloxacin
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Accelerating antimicrobial stewardship: An AI-CDSS approach to combating multidrug-resistant pathogens in the era of increasing resistance.

Clinica chimica acta; international journal of clinical chemistry Jun 15, 2025
OBJECTIVES: The World Health Organization has identified Klebsiella pneumoniae (KP) and Pseudomonas aeruginosa (PA) as significant public health threats owing to high antibiotic resistance. Traditional antibiotic susceptibility testing (AST) methods,...
Humans Artificial Intelligence Machine Learning Anti-Bacterial Agents Pseudomonas aeruginosa Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Antimicrobial Stewardship Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Decision Support Systems, Clinical Klebsiella pneumoniae
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Evolutionary accumulation modeling in AMR: machine learning to infer and predict evolutionary dynamics of multi-drug resistance.

mBio Jun 11, 2025
Can we understand and predict the evolutionary pathways by which bacteria acquire multi-drug resistance (MDR)? These questions have substantial potential impact in basic biology and in applied approaches to address the global health challenge of anti...
Humans Machine Learning Mycobacterium tuberculosis Anti-Bacterial Agents Drug Resistance, Multiple, Bacterial Bacteria Evolution, Molecular
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Machine learning for identifying resistance features of using whole-genome sequence single nucleotide polymorphisms.

Journal of medical microbiology Nov 1, 2021
, a gram-negative bacterium, is a common pathogen causing nosocomial infection. The drug-resistance rate of is increasing year by year, posing a severe threat to public health worldwide. has been listed as one of the pathogens causing the global c...
Tetracyclines Genome, Bacterial Amikacin Imipenem Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Polymorphism, Single Nucleotide Klebsiella pneumoniae Klebsiella Infections Gentamicins Cross Infection Humans Machine Learning
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Antimicrobial and synergistic activity of thiazoline derivatives in combination with conventional antibiotics against multidrug resistant Staphylococcus aureus isolated from abscess drainage samples.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
Emergence and spread of multidrug resistant (MDR) Staphylococcus aureus strains is becoming major challenge in treatment of soft tissue infections. This study aimed to explore antimicrobial and synergistic antimicrobial potential of three commerciall...
Disk Diffusion Antimicrobial Tests Drainage Humans Thiazolidines Staphylococcal Infections Anti-Bacterial Agents Drug Therapy, Combination Drug Synergism Drug Resistance, Multiple, Bacterial Ribotyping Abscess Staphylococcus aureus Thiazoles
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