AIMC Topic: Erythrocytes

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Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.

European journal of medicinal chemistry Jan 31, 2018
Primaquine (PQ) is a commonly used drug that can prevent the transmission of Plasmodium falciparum malaria, however toxicity limits its use. We prepared five groups of PQ derivatives: amides 1a-k, ureas 2a-k, semicarbazides 3a,b, acylsemicarbazides 4...
Dose-Response Relationship, Drug Cell Line Amides Drug Screening Assays, Antitumor Antineoplastic Agents Rats Cell Proliferation Antimalarials Malaria, Falciparum Erythrocytes Primaquine Structure-Activity Relationship Plasmodium falciparum Machine Learning Molecular Structure Humans Animals
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Design and synthesis of cell selective α/β-diastereomeric peptidomimetic with potent in vivo antibacterial activity against methicillin resistant S. Aureus.

Bioorganic chemistry Dec 26, 2017
Design of therapeutically viable antimicrobial peptides with cell selectivity against microorganisms is an important step towards the development of new antimicrobial agents. Here, we report four de novo designed, short amphipathic sequences based on...
Lipid Bilayers Peptidomimetics Phosphatidylglycerols Erythrocytes Acinetobacter baumannii Hemolysis Stereoisomerism Methicillin-Resistant Staphylococcus aureus Mice, Inbred BALB C Amino Acid Sequence Enterococcus faecalis Phosphatidylcholines Pseudomonas aeruginosa Keratinocytes Animals Humans Microbial Sensitivity Tests Anti-Bacterial Agents Escherichia coli Female
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Calli Essential Oils Synergize with Lawsone against Multidrug Resistant Pathogens.

Molecules (Basel, Switzerland) Dec 20, 2017
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, includin...
Endothelial Cells Drug Resistance, Multiple, Fungal Naphthoquinones Umbilical Veins Rhizopus Tracheophyta Liposomes Drug Synergism Erythrocytes Plant Oils Candida Antifungal Agents Microbial Sensitivity Tests Oils, Volatile Drug Resistance, Multiple, Bacterial Cell Survival Humans Anti-Bacterial Agents
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Label-free sensor for automatic identification of erythrocytes using digital in-line holographic microscopy and machine learning.

Biosensors & bioelectronics Dec 15, 2017
Cell types of erythrocytes should be identified because they are closely related to their functionality and viability. Conventional methods for classifying erythrocytes are time consuming and labor intensive. Therefore, an automatic and accurate eryt...
Humans Erythrocytes Pattern Recognition, Automated Machine Learning Cell Separation Biosensing Techniques Microscopy
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A deep convolutional neural network for classification of red blood cells in sickle cell anemia.

PLoS computational biology Oct 19, 2017
Sickle cell disease (SCD) is a hematological disorder leading to blood vessel occlusion accompanied by painful episodes and even death. Red blood cells (RBCs) of SCD patients have diverse shapes that reveal important biomechanical and bio-rheological...
Humans Neural Networks, Computer Image Interpretation, Computer-Assisted Erythrocytes Pattern Recognition, Automated Computational Biology Microscopy Anemia, Sickle Cell
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Deep Learning Makes Its Way to the Clinical Laboratory.

Clinical chemistry Oct 16, 2017
Neural Networks, Computer Deep Learning Erythrocytes Clinical Laboratory Services
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Very Deep Convolutional Neural Networks for Morphologic Classification of Erythrocytes.

Clinical chemistry Sep 6, 2017
BACKGROUND: Morphologic profiling of the erythrocyte population is a widely used and clinically valuable diagnostic modality, but one that relies on a slow manual process associated with significant labor cost and limited reproducibility. Automated p...
Image Processing, Computer-Assisted Erythrocytes Humans Neural Networks, Computer Databases, Factual
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Antihemolytic and antioxidant properties of pearl powder against 2,2'-azobis(2-amidinopropane) dihydrochloride-induced hemolysis and oxidative damage to erythrocyte membrane lipids and proteins.

Journal of food and drug analysis Dec 1, 2016
Pearl powder, a well-known traditional mineral medicine, is reported to be used for well-being and to treat several diseases from centuries in Taiwan and China. We investigated the in vitro antihemolytic and antioxidant properties of pearl powder tha...
Animals China Oxidative Stress Powders Erythrocytes Erythrocyte Membrane Antioxidants Pinctada Membrane Proteins Hemolysis Membrane Lipids Humans Amidines
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Automated Detection of P. falciparum Using Machine Learning Algorithms with Quantitative Phase Images of Unstained Cells.

PloS one Sep 16, 2016
Malaria detection through microscopic examination of stained blood smears is a diagnostic challenge that heavily relies on the expertise of trained microscopists. This paper presents an automated analysis method for detection and staging of red blood...
Machine Learning Algorithms Plasmodium falciparum Erythrocytes Automation Humans
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Single Molecule Fluorescence Microscopy and Machine Learning for Rhesus D Antigen Classification.

Scientific reports Sep 1, 2016
In transfusion medicine, the identification of the Rhesus D type is important to prevent anti-D immunisation in Rhesus D negative recipients. In particular, the detection of the very low expressed DEL phenotype is crucial and hence constitutes the bo...
Statistics as Topic Rh-Hr Blood-Group System Rho(D) Immune Globulin Phenotype Microscopy, Fluorescence Erythrocytes Humans Machine Learning
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