AIMC Topic: Extracellular Traps

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Circulating Neutrophil Extracellular Traps Signature for Identifying Organ Involvement and Response to Glucocorticoid in Adult-Onset Still's Disease: A Machine Learning Study.

Frontiers in immunology Nov 9, 2020
Adult-onset Still's disease (AOSD) is an autoinflammatory disease with multisystem involvement. Early identification of patients with severe complications and those refractory to glucocorticoid is crucial to improve therapeutic strategy in AOSD. Exag...
Extracellular Traps Support Vector Machine Case-Control Studies Treatment Outcome Cell-Free Nucleic Acids Still's Disease, Adult-Onset Adult Male Middle Aged Glucocorticoids Female Young Adult Cytokines Prognosis Humans
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Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis.

Journal of visualized experiments : JoVE Jun 18, 2020
Glomerular cell death is a pathological feature of myeloperoxidase anti neutrophil cytoplasmic antibody associated vasculitis (MPO-AAV). Extracellular deoxyribonucleic acid (ecDNA) is released during different forms of cell death including apoptosis,...
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis Kidney Glomerulus DNA Male Biopsy Image Processing, Computer-Assisted Peroxidase Extracellular Traps Glomerulonephritis Extracellular Space Models, Biological Supervised Machine Learning Humans Animals Mice, Inbred C57BL
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Convolutional Neural Networks-Based Image Analysis for the Detection and Quantification of Neutrophil Extracellular Traps.

Cells Feb 24, 2020
Over a decade ago, the formation of neutrophil extracellular traps (NETs) was described as a novel mechanism employed by neutrophils to tackle infections. Currently applied methods for NETs release quantification are often limited by the use of unspe...
Humans Neural Networks, Computer Extracellular Traps Neutrophils
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Machine Learning to Quantitate Neutrophil NETosis.

Scientific reports Nov 15, 2019
We introduce machine learning (ML) to perform classification and quantitation of images of nuclei from human blood neutrophils. Here we assessed the use of convolutional neural networks (CNNs) using free, open source software to accurately quantitate...
Humans Neural Networks, Computer Machine Learning Phenotype Reactive Oxygen Species Extracellular Traps Neutrophils Diagnostic Imaging Image Processing, Computer-Assisted Cell Death Necrosis Signal Transduction
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Azithromycin and Chloramphenicol Diminish Neutrophil Extracellular Traps (NETs) Release.

International journal of molecular sciences Dec 8, 2017
Neutrophils are one of the first cells to arrive at the site of infection, where they apply several strategies to kill pathogens: degranulation, respiratory burst, phagocytosis, and release of neutrophil extracellular traps (NETs). Antibiotics have a...
Phorbol 12,13-Dibutyrate Immunity, Innate Neutrophils Azithromycin Chloramphenicol Humans Apoptosis Infections Extracellular Traps
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The effect of Intravenous Immunoglobulin (IVIG) on \textit{ex vivo} activation of human leukocytes.

Human antibodies Jan 1, 2016
INTRODUCTION: Intravenous immunoglobulin (IVIG) has been widely used to treat various conditions, including inflammatory and autoimmune diseases. IVIG has been shown to have a direct influence on neutrophils, eosinophils and lymphocytes. However, man...
Tumor Necrosis Factor-alpha Lymphocyte Activation Primary Cell Culture Humans Immunoglobulins, Intravenous Leukocytes Dose-Response Relationship, Immunologic Tetradecanoylphorbol Acetate Extracellular Traps Healthy Volunteers Luminescent Measurements
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