Butyrylcholinesterase (BChE) may serve as a scavenger enzyme protecting against various toxic compounds, but we still don't fully understand how it interacts with fentanyl analogues. We investigated how Despropionyl -methyl fentanyl (DPPM) inhibits e...
The complexity and potency of the illicit opioid supply in North America has become increasingly concerning for people who use drugs. Drug checking efforts aim to keep up with the evolving psychoactive components present in the illicit drug supply. W...
The aim of this study was to develop and evaluate a liposomal formulation of fentanyl to improve its analgesic efficacy and safety profile in anesthesia, using artificial intelligence (AI) techniques to characterize and optimize the formulation. The ...
Fentanyl and its analogs are a global concern, making their accurate identification essential for public health. Here, we introduce Fentanyl-Hunter, a screening platform that uses a machine learning classifier and multilayer molecular network to sele...
BACKGROUND: Postinduction hypotension is a well-known risk factor for adverse postoperative outcomes. Anesthesiologists estimate anesthetic dosages based on a patient's chart and domain knowledge. Machine learning is increasingly applied in predictin...
Human nails have recently become a sample of interest for toxicological purposes. Multiple studies have proven the ability to detect various analytes within the keratin matrix of the nail. The analyte of interest in this study is fentanyl, a highly d...
Small (Weinheim an der Bergstrasse, Germany)
Apr 28, 2024
The opioid overdose crisis is a global health challenge. Fentanyl, an exceedingly potent synthetic opioid, has emerged as a leading contributor to the surge in opioid-related overdose deaths. The surge in overdose fatalities, particularly due to illi...
OBJECTIVE: To evaluate the perioperative analgesic effect of the unilateral lumbar erector spinae plane block (ESPB) in dogs undergoing hemilaminectomy.
Machine learning tools have demonstrated viability in visualizing pain accurately using vital sign data; however, it remains uncertain whether incorporating individual patient baselines could enhance accuracy. This study aimed to investigate improvin...
BACKGROUNDS: The duration and potency of the subarachnoid block (SAB) can be enhanced by incorporating spinal additives into local anesthetics. In this study, the effectiveness of intrathecal fentanyl and magnesium sulphate as adjuvant anesthetics to...
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