AIMC Topic: Gastrointestinal Microbiome
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Identification of KRAS mutation-associated gut microbiota in colorectal cancer and construction of predictive machine learning model.
Microbiology spectrum
Apr 4, 2024
Gut microbiota has demonstrated an increasingly important role in the onset and development of colorectal cancer (CRC). Nonetheless, the association between gut microbiota and KRAS mutation in CRC remains enigmatic. We conducted 16S rRNA sequencing o...
Artificial Intelligence-Guided Gut-Microenvironment-Triggered Imaging Sensor Reveals Potential Indicators of Parkinson's Disease.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Apr 3, 2024
The gut-brain axis has recently emerged as a crucial link in the development and progression of Parkinson's disease (PD). Dysregulation of the gut microbiota has been implicated in the pathogenesis of this disease, sparking growing interest in the qu...
Predicting the Rapid Progression of Mild Cognitive Impairment by Intestinal Flora and Blood Indicators through Machine Learning Method.
Neuro-degenerative diseases
Feb 28, 2024
INTRODUCTION: The aim of the work was to establish a prediction model of mild cognitive impairment (MCI) progression based on intestinal flora by machine learning method.
Smart capsules for sensing and sampling the gut: status, challenges and prospects.
Gut
Dec 7, 2023
Smart capsules are developing at a tremendous pace with a promise to become effective clinical tools for the diagnosis and monitoring of gut health. This field emerged in the early 2000s with a successful translation of an endoscopic capsule from lab...
Machine learning approach reveals microbiome, metabolome, and lipidome profiles in type 1 diabetes.
Journal of advanced research
Nov 30, 2023
INTRODUCTION: Type 1 diabetes (T1D) is a complex disorder influenced by genetic and environmental factors. The gut microbiome, the serum metabolome, and the serum lipidome have been identified as key environmental factors contributing to the pathophy...
GutBug: A Tool for Prediction of Human Gut Bacteria Mediated Biotransformation of Biotic and Xenobiotic Molecules Using Machine Learning.
Journal of molecular biology
Mar 22, 2023
Dietary components and bioactive molecules present in functional foods and nutraceuticals provide various beneficial effects including modulation of host gut microbiome. These metabolites along with orally administered drugs can be potentially bio-tr...
Overcoming regional limitations: transfer learning for cross-regional microbial-based diagnosis of diseases.
Gut
Oct 28, 2022
Anti-Colorectal Cancer Effects of (Bull.: Fr.) P. Karst. Spore Powder through Regulation of Gut Microbiota-Mediated JAK/STAT Signaling.
Nutrients
Aug 12, 2022
(Bull.: Fr.) P. Karst. spore powder (IHS) contains polyphenols and triterpenoids with pharmacological effects. Here, we analyzed its composition, and we investigated the effects of IHS on colorectal cancer (CRC) in B6/JGpt-/Gpt () mice and its poten...
The involvement of gut microbiota in the anti-tumor effect of carnosic acid via IL-17 suppression in colorectal cancer.
Chemico-biological interactions
Aug 1, 2022
Colorectal cancer (CRC) is a malignant tumor that threatens human health worldwide. Disturbance of the gut microbiota caused by various external factors is one of the leading causes. Carnosic acid (CA) is a phenolic diterpene compound, mainly isolate...
ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function.
Aging
Jun 8, 2022
Zhenqi Fuzheng formula (ZQFZ), of which the main ingredients are and , has immune system regulatory functions and potential anti-tumor bioactivity. The inhibition of colorectal tumor growth by ZQFZ was analyzed in inflammatory cells and B6/JGpt-/Gpt...
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