AIMC Topic: Genome-Wide Association Study

Clear Filters Showing 51 to 60 of 295 articles

Valid inference for machine learning-assisted genome-wide association studies.

Nature genetics Sep 30, 2024
Machine learning (ML) has become increasingly popular in almost all scientific disciplines, including human genetics. Owing to challenges related to sample collection and precise phenotyping, ML-assisted genome-wide association study (GWAS), which us...
Humans Machine Learning Algorithms Phenotype Bone Density Genome-Wide Association Study Polymorphism, Single Nucleotide
View on PubMed DOI

Machine Learning-Aided Ultra-Low-Density Single Nucleotide Polymorphism Panel Helps to Identify the Tharparkar Cattle Breed: Lessons for Digital Transformation in Livestock Genomics.

Omics : a journal of integrative biology Sep 20, 2024
Cattle breed identification is crucial for livestock research and sustainable food systems, and advances in genomics and artificial intelligence present new opportunities to address these challenges. This study investigates the identification of the ...
Genome-Wide Association Study Cattle Genomics Polymorphism, Single Nucleotide Breeding Machine Learning Animals Livestock
View on PubMed DOI

Predicting structure-targeted food bioactive compounds for middle-aged and elderly Asians with myocardial infarction: insights from genetic variations and bioinformatics-integrated deep learning analysis.

Food & function Sep 16, 2024
Myocardial infarction (MI) is a significant global health issue. Despite the advances in genome-wide association studies, a complete genetic and molecular understanding of MI is elusive and needs to be fully explored. This study aimed to elucidate th...
Male Middle Aged Molecular Docking Simulation Humans Female Aged Phytochemicals Myocardial Infarction Deep Learning Asian People Genome-Wide Association Study Genetic Variation Computational Biology
View on PubMed DOI

Semi-supervised machine learning method for predicting homogeneous ancestry groups to assess Hardy-Weinberg equilibrium in diverse whole-genome sequencing studies.

American journal of human genetics Sep 12, 2024
Large-scale, multi-ethnic whole-genome sequencing (WGS) studies, such as the National Human Genome Research Institute Genome Sequencing Program's Centers for Common Disease Genomics (CCDG), play an important role in increasing diversity for genetic r...
Genetics, Population Humans Supervised Machine Learning Polymorphism, Single Nucleotide Genome-Wide Association Study Genotype Ethnicity Whole Genome Sequencing Genome, Human
View on PubMed DOI

Disease prediction with multi-omics and biomarkers empowers case-control genetic discoveries in the UK Biobank.

Nature genetics Sep 11, 2024
The emergence of biobank-level datasets offers new opportunities to discover novel biomarkers and develop predictive algorithms for human disease. Here, we present an ensemble machine-learning framework (machine learning with phenotype associations, ...
Polymorphism, Single Nucleotide Multiomics Proteomics Case-Control Studies Genome-Wide Association Study Genetic Predisposition to Disease UK Biobank Biological Specimen Banks United Kingdom Multifactorial Inheritance Humans Machine Learning Algorithms Phenotype Biomarkers
View on PubMed DOI

Exploring genomic feature selection: A comparative analysis of GWAS and machine learning algorithms in a large-scale soybean dataset.

The plant genome Sep 10, 2024
The surge in high-throughput technologies has empowered the acquisition of vast genomic datasets, prompting the search for genetic markers and biomarkers relevant to complex traits. However, grappling with the inherent complexities of high dimensiona...
Phenotype Genome-Wide Association Study Genomics Polymorphism, Single Nucleotide Glycine max Genome, Plant Machine Learning Algorithms
View on PubMed DOI

Machine learning phenotyping and GWAS reveal genetic basis of Cd tolerance and absorption in jute.

Environmental pollution (Barking, Essex : 1987) Sep 10, 2024
Cadmium (Cd) is a dangerous environmental contaminant. Jute (Corchorus sp.) is an important natural fiber crop with strong absorption and excellent adaptability to metal-stressed environments, used in the phytoextraction of heavy metals. Understandin...
Machine Learning Phenotype Cadmium Genome-Wide Association Study Soil Pollutants Biodegradation, Environmental
View on PubMed DOI

Holistic understanding of trimethoprim resistance in using an integrative approach of genome-wide association study, resistance reconstruction, and machine learning.

mBio Aug 9, 2024
UNLABELLED: Antimicrobial resistance (AMR) is a public health threat worldwide. Next-generation sequencing (NGS) has opened unprecedented opportunities to accelerate AMR mechanism discovery and diagnostics. Here, we present an integrative approach to...
Mutation High-Throughput Nucleotide Sequencing Pneumococcal Infections Anti-Bacterial Agents Microbial Sensitivity Tests Genome-Wide Association Study Trimethoprim Resistance Humans Streptococcus pneumoniae Machine Learning Trimethoprim Genome, Bacterial
View on PubMed DOI

SR-TWAS: leveraging multiple reference panels to improve transcriptome-wide association study power by ensemble machine learning.

Nature communications Aug 5, 2024
Multiple reference panels of a given tissue or multiple tissues often exist, and multiple regression methods could be used for training gene expression imputation models for transcriptome-wide association studies (TWAS). To leverage expression imputa...
Alzheimer Disease Substantia Nigra Humans Genome-Wide Association Study Machine Learning Genetic Predisposition to Disease Gene Expression Profiling Parkinson Disease Transcriptome Dementia
View on PubMed DOI

Analyzing Medicago spp. seed morphology using GWAS and machine learning.

Scientific reports Jul 30, 2024
Alfalfa is widely recognized as an important forage crop. To understand the morphological characteristics and genetic basis of seed morphology in alfalfa, we screened 318 Medicago spp., including 244 Medicago sativa subsp. sativa (alfalfa) and 23 oth...
Genome, Plant Polymorphism, Single Nucleotide Machine Learning Quantitative Trait Loci Seeds Phenotype Medicago Medicago sativa Genome-Wide Association Study Medicago truncatula
View on PubMed DOI
Popular Topics
Recent Journals