AIMC Topic: Gram-Positive Bacteria

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In vitro activity of eravacycline against 2213 Gram-negative and 2424 Gram-positive bacterial pathogens isolated in Canadian hospital laboratories: CANWARD surveillance study 2014-2015.

Diagnostic microbiology and infectious disease Dec 22, 2017
Gram-negative (n=2213) and Gram-positive (n=2424) pathogens isolated from patients in 13 Canadian hospitals in 2014 and 2015 were tested for in vitro susceptibility to eravacycline and comparators using the Clinical and Laboratory Standards Institute...
Gram-Positive Bacteria Gram-Positive Bacterial Infections Enterobacteriaceae Infections Anti-Bacterial Agents Canada Microbial Sensitivity Tests Enterobacteriaceae Gram-Negative Bacteria Humans Tetracyclines Epidemiological Monitoring Gram-Negative Bacterial Infections Laboratories, Hospital
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An evidence of C16 fatty acid methyl esters extracted from microalga for effective antimicrobial and antioxidant property.

Microbial pathogenesis Dec 22, 2017
Fatty acid methyl esters (FAME) derived from lipids of microalgae is known to have wide bio-functional materials including antimicrobials. FAME is an ideal super-curator and superior anti-pathogenic. The present study evaluated the efficiency of FAME...
Microalgae Gram-Negative Bacteria Gram-Positive Bacteria Palmitates Scenedesmus Antioxidants Antifungal Agents Fungi Anti-Bacterial Agents Microbial Sensitivity Tests
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Antibacterial mechanisms of a novel type picosecond laser-generated silver-titanium nanoparticles and their toxicity to human cells.

International journal of nanomedicine Dec 20, 2017
In this study, we explored the antibacterial mechanisms for a novel type of Ag-TiO compound nanoparticles (NPs) produced from an Ag-TiO alloy using a picosecond laser and evaluated the toxicity of the Ag-TiO NPs to a range of human cell types. Transm...
Pseudomonas aeruginosa Humans Lasers Anti-Bacterial Agents HEK293 Cells Escherichia coli Methicillin-Resistant Staphylococcus aureus Metal Nanoparticles Gram-Positive Bacteria Titanium Cell Line Microscopy, Electron, Transmission Silver Reactive Oxygen Species
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Design, synthesis, antibacterial evaluation and molecular docking studies of some new quinoxaline derivatives targeting dihyropteroate synthase enzyme.

Bioorganic chemistry Dec 5, 2017
Development of new antimicrobial agents is a good solution to overcome drug-resistance problems. From this perspective, new quinoxaline derivatives bearing various bioactive heterocyclic moieties (thiadiazoles, oxadiazoles, pyrazoles and thiazoles) w...
Yersinia pestis Catalytic Domain Anti-Bacterial Agents Gram-Negative Bacteria Molecular Docking Simulation Structure-Activity Relationship Gram-Positive Bacteria Molecular Structure Hydrogen Bonding Drug Design Hydrophobic and Hydrophilic Interactions Quinoxalines Dihydropteroate Synthase Microbial Sensitivity Tests Levofloxacin Protein Binding
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Synthesis and antimicrobial studies of novel derivatives of 4-(4-formyl-3-phenyl-1H-pyrazol-1-yl)benzoic acid as potent anti-Acinetobacter baumannii agents.

Bioorganic & medicinal chemistry letters Dec 29, 2016
Microbial resistance to antibiotics is a global concern. The World Health Organization (WHO) has identified antimicrobial resistance as one the three greatest threats for human beings in the 21st century. Without urgent and coordinated action, the wo...
Catalytic Domain Acinetobacter baumannii Benzoic Acid Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Structure-Activity Relationship Binding Sites Pyrazoles Gram-Negative Bacteria Gram-Positive Bacteria Anti-Infective Agents Molecular Docking Simulation
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Predict Gram-Positive and Gram-Negative Subcellular Localization via Incorporating Evolutionary Information and Physicochemical Features Into Chou's General PseAAC.

IEEE transactions on nanobioscience Nov 12, 2015
In this study, we used structural and evolutionary based features to represent the sequences of gram-positive and gram-negative subcellular localizations. To do this, we proposed a normalization method to construct a normalize Position Specific Scori...
Gram-Negative Bacteria Gram-Positive Bacteria Intracellular Space Support Vector Machine Models, Statistical Bayes Theorem
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Multi-location gram-positive and gram-negative bacterial protein subcellular localization using gene ontology and multi-label classifier ensemble.

BMC bioinformatics Aug 25, 2015
BACKGROUND: It has become a very important and full of challenge task to predict bacterial protein subcellular locations using computational methods. Although there exist a lot of prediction methods for bacterial proteins, the majority of these metho...
Bacterial Proteins Gram-Negative Bacteria Gram-Positive Bacteria Protein Transport Gene Ontology Intracellular Space
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Designing antimicrobial peptides using deep learning and molecular dynamic simulations.

Briefings in bioinformatics Mar 19, 2023
With the emergence of multidrug-resistant bacteria, antimicrobial peptides (AMPs) offer promising options for replacing traditional antibiotics to treat bacterial infections, but discovering and designing AMPs using traditional methods is a time-cons...
Molecular Dynamics Simulation Gram-Negative Bacteria Gram-Positive Bacteria Antimicrobial Peptides Anti-Bacterial Agents Deep Learning Antimicrobial Cationic Peptides
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Deep-ABPpred: identifying antibacterial peptides in protein sequences using bidirectional LSTM with word2vec.

Briefings in bioinformatics Sep 2, 2021
The overuse of antibiotics has led to emergence of antimicrobial resistance, and as a result, antibacterial peptides (ABPs) are receiving significant attention as an alternative. Identification of effective ABPs in lab from natural sources is a cost-...
Gram-Positive Bacteria Viral Tail Proteins Streptococcus Phages Computational Biology Amino Acid Sequence Gram-Negative Bacteria Peptides Deep Learning Anti-Bacterial Agents Drug Resistance, Bacterial
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Distribution of main Gram-positive pathogens causing bloodstream infections in United States and European hospitals during the SENTRY Antimicrobial Surveillance Program (2010-2016): concomitant analysis of oritavancin in vitro activity.

Journal of chemotherapy (Florence, Italy) Sep 1, 2018
This study updates the distribution and trends of Gram-positive organisms causing bloodstream infections (BSIs) in the United States (US) and Europe during 2010-2016. In vitro activities of oritavancin and comparators were also evaluated. Staphylococ...
Cross Infection Humans Gram-Positive Bacteria Lipoglycopeptides Bacteremia Anti-Bacterial Agents Gram-Positive Bacterial Infections United States Hospitals Europe
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