European journal of nuclear medicine and molecular imaging
Feb 9, 2021
PURPOSE: Identification and delineation of the gross tumour and malignant nodal volume (GTV) in medical images are vital in radiotherapy. We assessed the applicability of convolutional neural networks (CNNs) for fully automatic delineation of the GTV...
International journal of radiation oncology, biology, physics
Feb 6, 2021
PURPOSE: Accurate lymph node (LN) malignancy classification is essential for treatment target identification in head and neck cancer (HNC) radiation therapy. Given the constraints imposed by relatively small sample sizes in real-world medical applica...
Transoral robotic surgery (TORS) is a novel surgical treatment of head and neck cancers, mainly for limited tumor in oropharynx and supraglottis. Despite the major advantage of favorable postoperative functional outcomes, many obstacles exist during ...
International journal of biological sciences
Jan 1, 2021
With the continuous development of medical image informatics technology, more and more high-throughput quantitative data could be extracted from digital medical images, which has resulted in a new kind of omics-Radiomics. In recent years, in addition...
Accurate segmentation of organs at risk (OARs) is necessary for adaptive head and neck (H&N) cancer treatment planning, but manual delineation is tedious, slow, and inconsistent. A self-channel-and-spatial-attention neural network (SCSA-Net) is devel...
Tumor mutation burden (TMB) is considered to be an independent genetic biomarker that can predict the tumor patient's response to immune checkpoint inhibitors (ICIs). Meanwhile, microRNA (miRNA) plays a key role in regulating the anticancer immune re...
Cone-beam computed tomography (CBCT)- and magnetic resonance (MR)-images allow a daily observation of patient anatomy but are not directly suited for accurate proton dose calculations. This can be overcome by creating synthetic CTs (sCT) using deep c...
BACKGROUND: Deep learning-based delineation of organs-at-risk for radiotherapy purposes has been investigated to reduce the time-intensiveness and inter-/intra-observer variability associated with manual delineation. We systematically evaluated ways ...
IMPORTANCE: Personalized radiotherapy planning depends on high-quality delineation of target tumors and surrounding organs at risk (OARs). This process puts additional time burdens on oncologists and introduces variability among both experts and inst...
This study proposes a near-real-time spot-scanning proton dose calculation method with probabilistic uncertainty estimation using a three-dimensional convolutional neural network (3D-CNN). CT images and clinical target volume contours of 215 head and...
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