AIMC Topic: HeLa Cells
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The application of convolution neural network based cell segmentation during cryopreservation.
Cryobiology
Sep 13, 2018
For most of the cells, water permeability and plasma membrane properties play a vital role in the optimal protocol for successful cryopreservation. Measuring the water permeability of cells during subzero temperature is essential. So far, there is no...
Improved Peptide Retention Time Prediction in Liquid Chromatography through Deep Learning.
Analytical chemistry
Aug 29, 2018
The accuracy of peptide retention time (RT) prediction model in liquid chromatography (LC) is still not sufficient for wider implementation in proteomics practice. Herein, we propose deep learning as an ideal tool to considerably improve this predict...
Identification of synthetic lethality based on a functional network by using machine learning algorithms.
Journal of cellular biochemistry
Aug 20, 2018
Synthetic lethality is the synthesis of mutations leading to cell death. Tumor-specific synthetic lethality has been targeted in research to improve cancer therapy. With the advances of techniques in molecular biology, such as RNAi and CRISPR/Cas9 ge...
Cell Segmentation Based on FOPSO Combined With Shape Information Improved Intuitionistic FCM.
IEEE journal of biomedical and health informatics
Feb 6, 2018
Fuzzy c-means (FCM) clustering algorithms have been proved to be effective image segmentation techniques. However, FCM clustering algorithms are sensitive to noises and initialization. They cannot effectively segment cell images with inhomogeneous gr...
Protective effect of aspirin against mitomycin C-induced carcinogenicity, assessed by the test for detection of epithelial tumor clones (warts) in Drosophila melanogaster.
Drug and chemical toxicology
Dec 27, 2017
The present study assessed the protective effect of aspirin against carcinogenicity induced by mitomycin C (MMC) by the test for detection of warts/epithelial tumor clones in Drosophila melanogaster. Larvae were treated with different concentrations ...
Synthesis and Evaluation of Biological Activities of Aziridine Derivatives of Urea and Thiourea.
Molecules (Basel, Switzerland)
Dec 25, 2017
In the present paper, we report the synthesis and evaluation of in vitro antimicrobial activities of aziridine-thiourea derivatives. A series of aziridines in reaction with isocyanates and isothiocyanates to obtain urea and thiourea derivatives were ...
Label-free detection of histone based on cationic conjugated polymer-mediated fluorescence resonance energy transfer.
Talanta
Dec 5, 2017
A simple and homogeneous histone assay is developed based on histone-induced DNA compressing coupled with cationic conjugated polymer (CCP)-mediated fluorescence resonance energy transfer (FRET). In this strategy, the CCP serves as the FRET donor and...
Integrating DNA structure switch with branched hairpins for the detection of uracil-DNA glycosylase activity and inhibitor screening.
Talanta
Nov 22, 2017
The detection of uracil-DNA glycosylase (UDG) activity is pivotal for its biochemical studies and the development of drugs for UDG-related diseases. Here, we explored an integrated DNA structure switch for high sensitive detection of UDG activity. Th...
Self-primer and self-template recycle rolling circle amplification strategy for sensitive detection of uracil-DNA glycosylase activity.
Analytica chimica acta
Nov 22, 2017
Sensitive and accurate detection of uracil-DNA glycosylase (UDG) activity is available for evaluating and validating their function in uracil base-excision repair (UBER) pathway and clinical diagnosis. Here, a sensitive and accurate method for UDG ac...
Cell cycle time series gene expression data encoded as cyclic attractors in Hopfield systems.
PLoS computational biology
Nov 17, 2017
Modern time series gene expression and other omics data sets have enabled unprecedented resolution of the dynamics of cellular processes such as cell cycle and response to pharmaceutical compounds. In anticipation of the proliferation of time series ...
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