Accurate identification of drug-target interactions (DTIs) plays a crucial role in drug discovery. Compared with traditional experimental methods that are labor-intensive and time-consuming, computational methods for drug-target interactions predicti...
BACKGROUND: Multiple studies have aimed to consolidate drug-related data and predict drug effects. However, most of these studies have focused on integrating diverse data through correlation rather than representing them based on the pharmacodynamic ...
CPT: pharmacometrics & systems pharmacology
Nov 17, 2024
Neural ordinary differential equations (NODEs) are an emerging machine learning (ML) method to model pharmacometric (PMX) data. Combining mechanism-based components to describe "known parts" and neural networks to learn "unknown parts" is a promising...
BACKGROUND: The anti-angiogenic drugs showed remarkable efficacy in the treatment of lung cancer. Nonetheless, the potential roles of the intra-tumoral immune cell abundances and peripheral blood immunological features in prognosis prediction of pati...
BACKGROUND: Accurate intraoperative tissue diagnostics could impact on decision making regarding the extent of resection (EOR) during brain tumor surgery. Stimulated Raman histology (SRH) is a label-free optical imaging method that uses different bio...
International journal of biological macromolecules
Nov 17, 2024
Diabetic foot ulcers (DFU) is a complication associated with diabetes characterised by high morbidity, disability, and mortality, involving chronic inflammation and infiltration of multiple immune cells. We aimed to identify the critical genes in non...
OBJECTIVES: One of the widely used optical biopsy methods for monitoring cellular and tissue metabolism is time-resolved fluorescence. The use of this method in optical liver biopsy has a high potential for studying the shift in energy-type productio...
In this society with a high incidence of cancer, cancer screening has become an important method to reduce the incidence and mortality of cancer. Traditional cancer screening methods such as CT have certain limitations and are difficult to adapt to l...
Medical sciences (Basel, Switzerland)
Nov 17, 2024
Quantum computing (QC) represents a paradigm shift in computational power, offering unique capabilities for addressing complex problems that are infeasible for classical computers. This review paper provides a detailed account of the current state of...
Breast cancer (BC) is a type of cancer which progresses and spreads from breast tissues and gradually exceeds the entire body; this kind of cancer originates in both sexes. Prompt recognition of this disorder is most significant in this phase, and it...
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