Biochemical and biophysical research communications
Dec 17, 2025
The dry fruits of Amomum villosum (Av) are a traditional Chinese medicine used for gastrointestinal disease. Aromatic oil has been reported to have anti-tumor properties. However, its therapeutic potential and molecular mechanisms remain unclear. Int...
Accurate segmentation of glioblastoma subregions from multi-parametric MRI is essential for diagnosis, surgical planning, and treatment monitoring in neuro-oncology. However, effective delineation of surrounding non-enhancing FLAIR hyperintensity, no...
Convolutional neural networks (CNNs) have achieved remarkable accuracy in histopathology image classification, yet their decision logic remains largely opaque. Most explainability methods, such as Grad-CAM or SHAP, provide only coarse heatmaps, offer...
Endocrine-disrupting chemicals (EDCs) are pervasive environmental hazards that have been linked to osteoporosis (OP), though causal mechanisms remain elusive. Employing an integrated multiomics framework, this study combined bidirectional Mendelian r...
Exosomal long noncoding RNAs (lncRNA) have significant potential as a biomarker for early cancer diagnosis. Accurate and sensitive detection of this abnormal expression remains challenging. Herein, we develop an innovative dual-mode photoelectrochemi...
The convergence of synthetic biology and biosensor technology is driving a scientific and technological revolution in biotechnology. Characterized by its interdisciplinary nature, synthetic biology applies engineering principles to design and constru...
Toxicological studies have demonstrated that disinfection byproducts (DBPs) can disrupt thyroid function; however, human epidemiological evidence remains limited. The existing studies focus on a limited number of compounds and lack detailed investiga...
Journal of chemical information and modeling
Dec 17, 2025
The accurate identification of drug-target interactions is crucial for shortening the timeline and lowering the expenses of pharmaceutical research, as the discovery of novel drugs remains a highly complex, resource-intensive, and lengthy endeavor. D...
Journal of chemical information and modeling
Dec 17, 2025
Accurate prediction of microbe-drug associations (MDAs) is vital for guiding antimicrobial therapy and accelerating drug repositioning. Although experimental validation remains the gold standard, it is costly and time-consuming. Existing models, ofte...
The escalating global burden of Alzheimer's disease (AD), projected to reach $16.9 trillion by 2050 with disproportionate impacts on low- and middle-income countries and racial minorities, underscores an urgent need for accessible early detection too...
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