International journal of environmental research and public health
Jan 19, 2021
Improving global health requires making current and future drugs more effective and affordable. While healthcare systems around the world are faced with increasing costs, branded and generic drug companies are facing the challenge of creating market...
GOAL: To develop and validate a field-based data collection and assessment method for human activity recognition in the mountains with variations in terrain and fatigue using a single accelerometer and a deep learning model.
In computer-aided analysis of cardiac MRI data, segmentations of the left ventricle (LV) and myocardium are performed to quantify LV ejection fraction and LV mass, and they are performed after the identification of a short axis slice coverage, where ...
We develop a general computational approach for improving the accuracy of basecalling with Oxford Nanopore's 1D and related sequencing protocols. Our software PoreOver ( https://github.com/jordisr/poreover ) finds the consensus of two neural networks...
Although genome-wide DNA methylomes have demonstrated their clinical value as reliable biomarkers for tumor detection, subtyping, and classification, their direct biological impacts at the individual gene level remain elusive. Here we present Methyla...
PURPOSE: A recurrent neural network (RNN) and its variants such as gated recurrent unit-based RNN (GRU-RNN) were found to be very suitable for dose-volume histogram (DVH) prediction in our previously published work. Using the dosimetric information g...
INTRODUCTION: Patients with sepsis who present to an emergency department (ED) have highly variable underlying disease severity, and can be categorized from low to high risk. Development of a risk stratification tool for these patients is important f...
The evolution of healthcare, together with the changing behaviour of healthcare professionals, means that medical affairs functions of pharmaceutical organisations are constantly reinventing themselves. The emergence of digital ways of working, exped...
BACKGROUND: Early detection and prompt intervention for clinically deteriorating events are needed to improve clinical outcomes. There have been several attempts at this, including the introduction of rapid response teams (RRTs) with early warning sc...
Clinical pharmacology and therapeutics
Jan 18, 2021
The aim of this work is to estimate the area-under the blood concentration curve of tacrolimus (TAC) following b.i.d. or q.d. dosing in organ transplant patients, using Xgboost machine learning (ML) models. A total of 4,997 and 1,452 TAC interdose ar...
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