Air pollution poses a critical global public health challenge. Molecular-level initiating events, such as pollutant-protein interactions, can trigger cascades of biological responses that may contribute to adverse health effects. However, current met...
Proceedings of the National Academy of Sciences of the United States of America
Dec 11, 2025
Large language models (LLMs) have shown remarkable capabilities in algorithm design, but their effectiveness in solving data science challenges in real-world settings remains poorly understood. We conducted a classroom experiment in which graduate st...
BACKGROUND: Machine learning (ML) models show promise in predicting post-traumatic stress disorder (PTSD) treatment outcomes, but it is unknown how their predictions compare to those of clinicians. This study directly compared the accuracy of clinici...
Proton therapy treatment planning currently needs to account for relatively large range uncertainty margins primarily due to the semi-empirical calibration of the treatment planning x-ray computed tomography (CT) to proton stopping power relative to ...
Liquid biopsies are transforming oncology, enabling earlier diagnosis, dynamic treatment guidance, and personalized precision medicine, yet current approaches focusing mainly on circulating host cell-free DNA (cfDNA) neglect crucial information withi...
Immune checkpoint inhibitors have partially improved treatment outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but the response rate remains low, with only a few patients benefiting. Mechanistically, HNSCC tumor cells often ...
Chemical neuroscience wields tools to uncover the molecular mysteries of the brain. Sensors can be fabricated with properties tailored to the scales needed to decode neurochemical information. Current instrumentation is capable of measurement rates t...
Antimicrobial agents and chemotherapy
Dec 10, 2025
Dalbavancin is a long-acting lipoglycopeptide increasingly used off-label for complex Gram-positive infections requiring prolonged therapy. Its extended half-life enables simplified regimens, but interindividual pharmacokinetic variability and pathog...
Myocardial ischemia-reperfusion injury (MIRI), a frequent complication in acute myocardial infarction (AMI) treatment, arises from complex mechanisms including oxidative stress, inflammation, and mitochondrial dysfunction, which impair myocardial rep...
Journal of chemical information and modeling
Dec 10, 2025
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two important targets in current drug discovery, mainly due to the COVID-19 pandemic and the MERS-CoV outbreaks in recent yea...
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