AIMC Topic: Immunosuppressive Agents
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Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.
Clinical pharmacology in drug development
Dec 4, 2015
Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose o...
Knowledge retrieval from PubMed abstracts and electronic medical records with the Multiple Sclerosis Ontology.
PloS one
Feb 9, 2015
BACKGROUND: In order to retrieve useful information from scientific literature and electronic medical records (EMR) we developed an ontology specific for Multiple Sclerosis (MS).
Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.
Renal failure
Dec 1, 2025
Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference fo...
Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis.
Journal of medical Internet research
May 13, 2025
BACKGROUND: As the optimal treatment for end-stage renal disease, kidney transplantation has proven instrumental in enhancing patient survival and quality of life. Suboptimal medication adherence is recognized as an independent risk factor for poor p...
Interleukin-6 and interleukin-8 levels in children with aplastic anemia and its correlation with disease severity and response to immunosuppressive therapy.
Annals of African medicine
Jan 1, 2023
BACKGROUND: Aplastic anemia (AA) is an uncommon condition characterized by pancytopenia and hypocellular bone marrow. Interleukin (IL)-6 and IL-8 have been shown to inhibit myelopoiesis and are major mediators of tissue damage. The primary goal of th...
Estimation of Mycophenolic Acid Exposure in Chinese Renal Transplant Patients by a Joint Deep Learning Model.
Therapeutic drug monitoring
Dec 1, 2022
BACKGROUND: To predict mycophenolic acid (MPA) exposure in renal transplant recipients using a deep learning model based on a convolutional neural network with bilateral long short-term memory and attention methods.
Therapeutic monitoring of mycophenolic acid in renal transplanted patients by a validated HPLC method.
Folia medica
Oct 31, 2021
INTRODUCTION: Mycophenolate mofetil and its active metabolite mycophenolic acid are routinely used as immunosuppressant drugs in solid organ transplantation in a fixed daily dose regimen in association with cyclosporine, tacrolimus and steroids. Ther...
Application of machine intelligence technology in the detection of vaccines and medicines for SARS-CoV-2.
European review for medical and pharmacological sciences
Nov 1, 2020
Researchers have found many similarities between the 2003 severe acute respiratory syndrome (SARS) virus and SARS-CoV-19 through existing data that reveal the SARS's cause. Artificial intelligence (AI) learning models can be created to predict drug s...
Drug Repositioning
Vitamins
Ascorbic Acid
Ritonavir
Antibodies, Monoclonal, Humanized
Drug Combinations
Immunosuppressive Agents
Chloroquine
Hydroxychloroquine
Adenosine Monophosphate
COVID-19 Drug Treatment
Ribavirin
Alanine
Lopinavir
Humans
Artificial Intelligence
Machine Learning
COVID-19
Deep Learning
Antiviral Agents
COVID-19 Vaccines
Drug Development
Artificial neural network and bioavailability of the immunosuppression drug.
Current opinion in organ transplantation
Aug 1, 2020
PURPOSE OF REVIEW: The success of organ transplant is determined by number of demographic, clinical, immunological and genetic variables. Artificial intelligence tools, such as artificial neural networks (ANNs) or classification and regression trees ...
The Association Between Arthralgia and Vedolizumab Using Natural Language Processing.
Inflammatory bowel diseases
Sep 15, 2018
BACKGROUND: The gut-selective nature of vedolizumab has raised questions regarding increased joint pain or arthralgia with its use in inflammatory bowel disease (IBD) patients. As arthralgias are seldom coded and thus difficult to study, few studies ...
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