Tacrolimus has a narrow therapeutic window and considerable variability in clinical use. Our goal was to compare the performance of multiple linear regression (MLR) and eight machine learning techniques in pharmacogenetic algorithm-based prediction o...
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...
Clinical pharmacology in drug development
Dec 4, 2015
Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose o...
BACKGROUND: In order to retrieve useful information from scientific literature and electronic medical records (EMR) we developed an ontology specific for Multiple Sclerosis (MS).
Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference fo...
BACKGROUND: Epidemiological studies on idiopathic nephrotic syndrome (INS) in children have identified no definitive factors predicting steroid-resistant nephrotic syndrome (SRNS) or frequent relapsing nephrotic syndrome. Research using machine learn...
OBJECTIVE: This study aimed to improve treatment effectiveness in childhood-onset systemic lupus erythematosus (cSLE) by developing machine learning algorithms integrated with pharmacokinetic parameters to predict individualized tacrolimus dosing for...
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
BACKGROUND: As the optimal treatment for end-stage renal disease, kidney transplantation has proven instrumental in enhancing patient survival and quality of life. Suboptimal medication adherence is recognized as an independent risk factor for poor p...
BACKGROUND: Aplastic anemia (AA) is an uncommon condition characterized by pancytopenia and hypocellular bone marrow. Interleukin (IL)-6 and IL-8 have been shown to inhibit myelopoiesis and are major mediators of tissue damage. The primary goal of th...
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