AIMC Topic: Immunosuppressive Agents
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Adequate tacrolimus concentration for myasthenia gravis treatment.
European journal of neurology
Nov 7, 2016
BACKGROUND AND PURPOSE: A single, oral dose of 3 mg/day tacrolimus, approved for myasthenia gravis (MG) treatment in Japan, was shown to reduce steroid dose and anti-acetylcholine receptor (AChR) antibody titers as well as to improve MG symptoms. How...
Relative Bioavailability of a Single Dose of Belimumab Administered Subcutaneously by Prefilled Syringe or Autoinjector in Healthy Subjects.
Clinical pharmacology in drug development
Dec 4, 2015
Intravenous belimumab is approved for the treatment of systemic lupus erythematosus; subcutaneous self-administration would enable greater patient access. This study assessed relative bioavailability, tolerability, and safety of 1 subcutaneous dose o...
Knowledge retrieval from PubMed abstracts and electronic medical records with the Multiple Sclerosis Ontology.
PloS one
Feb 9, 2015
BACKGROUND: In order to retrieve useful information from scientific literature and electronic medical records (EMR) we developed an ontology specific for Multiple Sclerosis (MS).
Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.
Renal failure
Dec 1, 2025
Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs) are widely used biomarkers for immune monitoring, yet there is no established standard reference fo...
Applying exposure-response analysis to enhance Mycophenolate Mofetil dosing precision in pediatric patients with immune-mediated renal diseases by machine learning models.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Aug 1, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
Effectiveness of eHealth for Medication Adherence in Renal Transplant Recipients: Systematic Review and Meta-Analysis.
Journal of medical Internet research
May 13, 2025
BACKGROUND: As the optimal treatment for end-stage renal disease, kidney transplantation has proven instrumental in enhancing patient survival and quality of life. Suboptimal medication adherence is recognized as an independent risk factor for poor p...
Interleukin-6 and interleukin-8 levels in children with aplastic anemia and its correlation with disease severity and response to immunosuppressive therapy.
Annals of African medicine
Jan 1, 2023
BACKGROUND: Aplastic anemia (AA) is an uncommon condition characterized by pancytopenia and hypocellular bone marrow. Interleukin (IL)-6 and IL-8 have been shown to inhibit myelopoiesis and are major mediators of tissue damage. The primary goal of th...
Estimation of Mycophenolic Acid Exposure in Chinese Renal Transplant Patients by a Joint Deep Learning Model.
Therapeutic drug monitoring
Dec 1, 2022
BACKGROUND: To predict mycophenolic acid (MPA) exposure in renal transplant recipients using a deep learning model based on a convolutional neural network with bilateral long short-term memory and attention methods.
Therapeutic monitoring of mycophenolic acid in renal transplanted patients by a validated HPLC method.
Folia medica
Oct 31, 2021
INTRODUCTION: Mycophenolate mofetil and its active metabolite mycophenolic acid are routinely used as immunosuppressant drugs in solid organ transplantation in a fixed daily dose regimen in association with cyclosporine, tacrolimus and steroids. Ther...
Application of machine intelligence technology in the detection of vaccines and medicines for SARS-CoV-2.
European review for medical and pharmacological sciences
Nov 1, 2020
Researchers have found many similarities between the 2003 severe acute respiratory syndrome (SARS) virus and SARS-CoV-19 through existing data that reveal the SARS's cause. Artificial intelligence (AI) learning models can be created to predict drug s...
Lopinavir
Chloroquine
Hydroxychloroquine
Adenosine Monophosphate
Immunosuppressive Agents
Drug Repositioning
Vitamins
Ascorbic Acid
Ritonavir
COVID-19 Drug Treatment
Ribavirin
Alanine
Humans
COVID-19 Vaccines
Artificial Intelligence
Drug Development
Machine Learning
COVID-19
Antibodies, Monoclonal, Humanized
Deep Learning
Drug Combinations
Antiviral Agents
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