AIMC Topic: Klebsiella pneumoniae

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Antimicrobial Activity Classification of Imidazolium Derivatives Predicted by Artificial Neural Networks.

Pharmaceutical research Apr 17, 2024
PURPOSE: This study assesses the Multilayer Perceptron (MLP) neural network, complemented by other Machine Learning techniques (CART, PCA), in predicting the antimicrobial activity of 140 newly designed imidazolium chlorides against Klebsiella pneumo...
Neural Networks, Computer Microbial Sensitivity Tests Klebsiella pneumoniae Machine Learning Imidazoles Anti-Bacterial Agents Principal Component Analysis Anti-Infective Agents
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Combining deep learning and droplet microfluidics for rapid and label-free antimicrobial susceptibility testing of colistin.

Biosensors & bioelectronics Apr 16, 2024
Efficient tools for rapid antibiotic susceptibility testing (AST) are crucial for appropriate use of antibiotics, especially colistin, which is now often considered a last resort therapy with extremely drug resistant Gram-negative bacteria. Here, we ...
Colistin Lab-On-A-Chip Devices Escherichia coli Equipment Design Microfluidics Humans Anti-Bacterial Agents Biosensing Techniques Klebsiella pneumoniae Deep Learning Microbial Sensitivity Tests
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Machine learning and molecular simulation ascertain antimicrobial peptide against Klebsiella pneumoniae from public database.

Computational biology and chemistry Dec 5, 2022
Antimicrobial peptides (AMPs) are short peptides with a broad spectrum of antimicrobial activity. They play a key role in the host innate immunity of many organisms. The growing threat of microorganisms resistant to antimicrobial agents and the lack ...
Antimicrobial Peptides Klebsiella pneumoniae Molecular Dynamics Simulation Machine Learning Ligands Anti-Bacterial Agents Molecular Docking Simulation
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ICEO, a biological ontology for representing and analyzing bacterial integrative and conjugative elements.

Scientific data Jan 20, 2022
Bacterial integrative and conjugative elements (ICEs) are highly modular mobile genetic elements critical to the horizontal transfer of antibiotic resistance and virulence factor genes. To better understand and analyze the ongoing increase of ICEs, w...
Gene Transfer, Horizontal DNA Transposable Elements Conjugation, Genetic Klebsiella pneumoniae Biological Ontologies
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Direct antimicrobial resistance prediction from clinical MALDI-TOF mass spectra using machine learning.

Nature medicine Jan 10, 2022
Early use of effective antimicrobial treatments is critical for the outcome of infections and the prevention of treatment resistance. Antimicrobial resistance testing enables the selection of optimal antibiotic treatments, but current culture-based t...
Humans Machine Learning Anti-Bacterial Agents Escherichia coli Staphylococcus aureus Drug Resistance, Microbial Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Retrospective Studies Microbial Sensitivity Tests Klebsiella pneumoniae
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Identification of antibiotic resistance and virulence-encoding factors in Klebsiella pneumoniae by Raman spectroscopy and deep learning.

Microbial biotechnology Nov 29, 2021
Klebsiella pneumoniae has become the number one bacterial pathogen that causes high mortality in clinical settings worldwide. Clinical K. pneumoniae strains with carbapenem resistance and/or hypervirulent phenotypes cause higher mortality comparing w...
Spectrum Analysis, Raman Drug Resistance, Microbial Virulence Factors Virulence Deep Learning Klebsiella pneumoniae Klebsiella Infections Humans Anti-Bacterial Agents
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Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations.

Nature biomedical engineering Mar 11, 2021
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report an efficient computational method for the generation of antimicrob...
Anti-Bacterial Agents Acinetobacter baumannii Drug Resistance, Bacterial Female Animals Drug Design Drug Discovery Staphylococcus aureus Mice, Inbred BALB C Antimicrobial Cationic Peptides Amino Acid Sequence Pseudomonas aeruginosa Structure-Activity Relationship Molecular Dynamics Simulation Klebsiella pneumoniae Klebsiella Infections Escherichia coli Deep Learning Microbial Sensitivity Tests Mice
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Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using supervised machine learning approach.

PloS one Feb 6, 2020
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a significant pathogen causing healthcare-associated infections. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight mass spectrometry (MALDI-TOF MS...
Cross Infection Carbapenem-Resistant Enterobacteriaceae Random Amplified Polymorphic DNA Technique Supervised Machine Learning Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Carbapenems Humans Klebsiella pneumoniae DNA, Bacterial Klebsiella Infections Predictive Value of Tests Algorithms Anti-Bacterial Agents Microbial Sensitivity Tests
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Performance of neural network basecalling tools for Oxford Nanopore sequencing.

Genome biology Jun 24, 2019
BACKGROUND: Basecalling, the computational process of translating raw electrical signal to nucleotide sequence, is of critical importance to the sequencing platforms produced by Oxford Nanopore Technologies (ONT). Here, we examine the performance of ...
Sequence Analysis, DNA Nanopores Neural Networks, Computer Software Klebsiella pneumoniae
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In vitro activity of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Korea.

Diagnostic microbiology and infectious disease Nov 26, 2018
To find an alternative regimen for the treatment of extended-spectrum β-lactamase (EBSL)-producing Enterobacteriaceae infections, we examined the in vitro activity of flomoxef against Escherichia coli and Klebsiella pneumoniae having CTX-M-1 group an...
Escherichia coli Infections Cephalosporins beta-Lactamases Escherichia coli Proteins Hospitals, University Klebsiella pneumoniae Humans Korea Klebsiella Infections Anti-Bacterial Agents Escherichia coli Microbial Sensitivity Tests
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