AIMC Topic: Knowledge Bases

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A knowledge-based system to find over-the-counter medicines for self-medication.

Journal of biomedical informatics
This study developed a medicine query system based on Semantic Web and open data especially for self-medication users to search over-the-counter (OTC) medicines. Most existing medicine query systems are based on keyword searches. If users are uncerta...

Building a PubMed knowledge graph.

Scientific data
PubMed is an essential resource for the medical domain, but useful concepts are either difficult to extract or are ambiguous, which has significantly hindered knowledge discovery. To address this issue, we constructed a PubMed knowledge graph (PKG) b...

A Knowledge-Based Machine Learning Approach to Gene Prioritisation in Amyotrophic Lateral Sclerosis.

Genes
Amyotrophic lateral sclerosis is a neurodegenerative disease of the upper and lower motor neurons resulting in death from neuromuscular respiratory failure, typically within two to five years of first symptoms. Several rare disruptive gene variants h...

A gentle introduction to deep learning for graphs.

Neural networks : the official journal of the International Neural Network Society
The adaptive processing of graph data is a long-standing research topic that has been lately consolidated as a theme of major interest in the deep learning community. The snap increase in the amount and breadth of related research has come at the pri...

Using Reactome to build an autophagy mechanism knowledgebase.

Autophagy
The 21st century has revealed much about the fundamental cellular process of autophagy. Autophagy controls the catabolism and recycling of various cellular components both as a constitutive process and as a response to stress and foreign material inv...

Developing knowledge-based planning for gynaecological and rectal cancers: a clinical validation of RapidPlan.

Journal of medical radiation sciences
INTRODUCTION: To create and clinically validate knowledge-based planning (KBP) models for gynaecologic (GYN) and rectal cancer patients. Assessment of ecologic generalisability and predictive validity of conventional planning versus single calculatio...

Bio-semantic relation extraction with attention-based external knowledge reinforcement.

BMC bioinformatics
BACKGROUND: Semantic resources such as knowledge bases contains high-quality-structured knowledge and therefore require significant effort from domain experts. Using the resources to reinforce the information retrieval from the unstructured text may ...

Similarity-Based Methods and Machine Learning Approaches for Target Prediction in Early Drug Discovery: Performance and Scope.

International journal of molecular sciences
Computational methods for predicting the macromolecular targets of drugs and drug-like compounds have evolved as a key technology in drug discovery. However, the established validation protocols leave several key questions regarding the performance a...

RadAtlas 1.0: a knowledgebase focusing on radiation-associated genes.

International journal of radiation biology
Ionizing radiation has very complex biological effects, such as inducing damage to DNA and proteins, ionizing water molecules to produce toxic free radicals, and triggering genetic and somatic effects. Understanding the biomolecular response mechani...

Knowledge Graph-Enabled Cancer Data Analytics.

IEEE journal of biomedical and health informatics
Cancer registries collect unstructured and structured cancer data for surveillance purposes which provide important insights regarding cancer characteristics, treatments, and outcomes. Cancer registry data typically (1) categorize each reportable can...