AIMC Topic: Dose Fractionation, Radiation

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Reduction of the planning target volume with daily online adaptive radiotherapy in bladder cancer.

Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]
INTRODUCTION: External radiation therapy for bladder cancer requires large planning target volumes (PTVs) due to the daily anatomy of the bladder. Online adaptive radiotherapy (oART) can reduce the PTV by considering daily anatomical changes.

5-5-5 ABRT (Dose of 5 Gy per Fraction for up to 5 Fractions Over 5 Weeks Adaptive Bridging Radiation Therapy)-Artificial Intelligence Enters the CAR (-T) (Chimeric Antigen Receptor-T) in Relapsed/Refractory Large B Cell Lymphoma.

International journal of radiation oncology, biology, physics
PURPOSE: Bridging radiation therapy (BRT) is effective for local control in patients with relapsed or refractory large B cell lymphoma who are undergoing chimeric antigen receptor (CAR) T cell therapy. We hypothesized that adaptive BRT (ABRT), which ...

Optimizing fractionation schedules for de-escalation radiotherapy in head and neck cancers using deep reinforcement learning.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology
PURPOSE: Patients with locally-advanced head and neck squamous cell carcinomas (HNSCCs), particularly those related to human papillomavirus (HPV), often achieve good locoregional control (LRC), yet they suffer significant toxicities from standard che...

A deep learning model for inter-fraction head and neck anatomical changes in proton therapy.

Physics in medicine and biology
To assess the performance of a probabilistic deep learning based algorithm for predicting inter-fraction anatomical changes in head and neck patients.A probabilistic daily anatomy model (DAM) for head and neck patients DAM (DAM) is built on the varia...

Personalized deep learning auto-segmentation models for adaptive fractionated magnetic resonance-guided radiation therapy of the abdomen.

Medical physics
BACKGROUND: Manual contour corrections during fractionated magnetic resonance (MR)-guided radiotherapy (MRgRT) are time-consuming. Conventional population models for deep learning auto-segmentation might be suboptimal for MRgRT at MR-Linacs since the...

A competing risks machine learning study of neutron dose, fractionation, age, and sex effects on mortality in 21,000 mice.

Scientific reports
This study explores the impact of densely-ionizing radiation on non-cancer and cancer diseases, focusing on dose, fractionation, age, and sex effects. Using historical mortality data from approximately 21,000 mice exposed to fission neutrons, we empl...

A Prospective Study of Machine Learning-Assisted Radiation Therapy Planning for Patients Receiving 54 Gy to the Brain.

International journal of radiation oncology, biology, physics
PURPOSE: The capacity for machine learning (ML) to facilitate radiation therapy (RT) planning for primary brain tumors has not been described. We evaluated ML-assisted RT planning with regard to clinical acceptability, dosimetric outcomes, and planni...

Developing knowledge-based planning for gynaecological and rectal cancers: a clinical validation of RapidPlan.

Journal of medical radiation sciences
INTRODUCTION: To create and clinically validate knowledge-based planning (KBP) models for gynaecologic (GYN) and rectal cancer patients. Assessment of ecologic generalisability and predictive validity of conventional planning versus single calculatio...

Fast contour propagation for MR-guided prostate radiotherapy using convolutional neural networks.

Medical physics
PURPOSE: To quickly and automatically propagate organ contours from pretreatment to fraction images in magnetic resonance (MR)-guided prostate external-beam radiotherapy.

2D ultrasound imaging based intra-fraction respiratory motion tracking for abdominal radiation therapy using machine learning.

Physics in medicine and biology
We have previously developed a robotic ultrasound imaging system for motion monitoring in abdominal radiation therapy. Owing to the slow speed of ultrasound image processing, our previous system could only track abdominal motions under breath-hold. T...