AIMC Topic: Knowledge Bases
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NDDRF 2.0: An update and expansion of risk factor knowledge base for personalized prevention of neurodegenerative diseases.
Alzheimer's & dementia : the journal of the Alzheimer's Association
May 1, 2025
INTRODUCTION: Neurodegenerative diseases (NDDs) are chronic diseases caused by brain neuron degeneration, requiring systematic integration of risk factors to address their heterogeneity. Established in 2021, Knowledgebase of Risk Factors for Neurodeg...
[Databases, knowledge bases, and large models for biomanufacturing].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Mar 25, 2025
Biomanufacturing is an advanced manufacturing method that integrates biology, chemistry, and engineering. It utilizes renewable biomass and biological organisms as production media to scale up the production of target products through fermentation. C...
IAMPDB: A Knowledgebase of Manually Curated Insects-Derived Antimicrobial Peptides.
Journal of peptide science : an official publication of the European Peptide Society
Mar 1, 2025
Insects, a majority of animal species, rely on innate immunity and antimicrobial peptides (AMPs), which are a part of their innate immunity, to combat diverse parasites and pathogens. These peptides have applications ranging from agriculture to antim...
BindingDB in 2024: a FAIR knowledgebase of protein-small molecule binding data.
Nucleic acids research
Jan 6, 2025
BindingDB (bindingdb.org) is a public, web-accessible database of experimentally measured binding affinities between small molecules and proteins, which supports diverse applications including medicinal chemistry, biochemical pathway annotation, trai...
PanKB: An interactive microbial pangenome knowledgebase for research, biotechnological innovation, and knowledge mining.
Nucleic acids research
Jan 6, 2025
The exponential growth of microbial genome data presents unprecedented opportunities for unlocking the potential of microorganisms. The burgeoning field of pangenomics offers a framework for extracting insights from this big biological data. Recent a...
UniProt: the Universal Protein Knowledgebase in 2025.
Nucleic acids research
Jan 6, 2025
The aim of the UniProt Knowledgebase (UniProtKB; https://www.uniprot.org/) is to provide users with a comprehensive, high-quality and freely accessible set of protein sequences annotated with functional information. In this publication, we describe o...
canSAR 2024-an update to the public drug discovery knowledgebase.
Nucleic acids research
Jan 6, 2025
canSAR (https://cansar.ai) continues to serve as the largest publicly available platform for cancer-focused drug discovery and translational research. It integrates multidisciplinary data from disparate and otherwise siloed public data sources as wel...
ASpdb: an integrative knowledgebase of human protein isoforms from experimental and AI-predicted structures.
Nucleic acids research
Jan 6, 2025
Alternative splicing is a crucial cellular process in eukaryotes, enabling the generation of multiple protein isoforms with diverse functions from a single gene. To better understand the impact of alternative splicing on protein structures, protein-p...
scTWAS Atlas: an integrative knowledgebase of single-cell transcriptome-wide association studies.
Nucleic acids research
Jan 6, 2025
Single-cell transcriptome-wide association studies (scTWAS) is a new method for conducting TWAS analysis at the cellular level to identify gene-trait associations with higher precision. This approach helps overcome the challenge of interpreting cell-...
OrgXenomics: an integrated proteomic knowledge base for patient-derived organoid and xenograft.
Nucleic acids research
Jan 6, 2025
Patient-derived models (PDMs, particularly organoids and xenografts) are irreplaceable tools for precision medicine, from target development to lead identification, then to preclinical evaluation, and finally to clinical decision-making. So far, PDM-...
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