AIMS: Morphological differentiation among different blast cell lineages is a difficult task and there is a lack of automated analysers able to recognise these abnormal cells. This study aims to develop a machine learning approach to predict the diagn...
Deep learning neural network models such as multilayer perceptron (MLP) and convolutional neural network (CNN) are novel and attractive artificial intelligence computing tools. However, evaluation of the performance of these methods is not readily av...
Clinicians often make multiple treatment decisions at key points over the course of a patient's disease. A dynamic treatment regime is a sequence of decision rules, each mapping a patient's observed history to the set of available, feasible treatment...
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
Feb 2, 2018
The survival of patients undergoing hematopoietic cell transplantation (HCT) from unrelated donors for acute leukemia exhibits considerable variation, even after stringent genetic matching. To improve the donor selection process, we attempted to crea...
This paper presents a novel method for salient object detection in nature image by simulating microsaccades in fixational eye movements. Due to a nucleated cell usually stained that is salient obviously, the proposed method is suitable to segment nuc...
Rare cell populations play a pivotal role in the initiation and progression of diseases such as cancer. However, the identification of such subpopulations remains a difficult task. This work describes CellCnn, a representation learning approach to de...
The identification of a subset of genes having the ability to capture the necessary information to distinguish classes of patients is crucial in bioinformatics applications. Ensemble and bagging methods have been shown to work effectively in the proc...
This research proposes an intelligent decision support system for acute lymphoblastic leukaemia diagnosis from microscopic blood images. A novel clustering algorithm with stimulating discriminant measures (SDM) of both within- and between-cluster sca...
For cancer classification problems based on gene expression, the data usually has only a few dozen sizes but has thousands to tens of thousands of genes which could contain a large number of irrelevant genes. A robust feature selection algorithm is r...
Leukemia is a common type of blood cancer marked by the abnormal and uncontrolled proliferation and expansion of white blood cells. This anomaly impacts the blood and bone marrow, diminishing the bone marrow's capacity to generate platelets and red b...
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