AIMC Topic: Luminescent Proteins
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Directed Evolution of Fluorescent Genetically Encoded Biosensors: Innovative Approaches for Development and Optimization of Biosensors.
Chembiochem : a European journal of chemical biology
Apr 4, 2025
Fluorescent protein-based biosensors are indispensable molecular tools in cell biology and biomedical research, providing non-invasive dynamic measurements of metabolite concentrations and other cellular signals. Traditional methods for developing th...
Machine-Learning-Guided Mutagenesis for Directed Evolution of Fluorescent Proteins.
ACS synthetic biology
Aug 20, 2018
Molecular evolution based on mutagenesis is widely used in protein engineering. However, optimal proteins are often difficult to obtain due to a large sequence space. Here, we propose a novel approach that combines molecular evolution with machine le...
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.
Nature chemical biology
Feb 26, 2018
We developed a new way to engineer complex proteins toward multidimensional specifications using a simple, yet scalable, directed evolution strategy. By robotically picking mammalian cells that were identified, under a microscope, as expressing prote...
Unsupervised learning assisted robust prediction of bioluminescent proteins.
Computers in biology and medicine
Nov 10, 2015
Bioluminescence plays an important role in nature, for example, it is used for intracellular chemical signalling in bacteria. It is also used as a useful reagent for various analytical research methods ranging from cellular imaging to gene expression...
A cellular platform for the development of synthetic living machines.
Science robotics
Mar 31, 2021
Robot swarms have, to date, been constructed from artificial materials. Motile biological constructs have been created from muscle cells grown on precisely shaped scaffolds. However, the exploitation of emergent self-organization and functional plast...
Deep Residual Neural Networks Resolve Quartet Molecular Phylogenies.
Molecular biology and evolution
May 1, 2020
Phylogenetic inference is of fundamental importance to evolutionary as well as other fields of biology, and molecular sequences have emerged as the primary data for this task. Although many phylogenetic methods have been developed to explicitly take ...
Microfluidic cap-to-dispense (μCD): a universal microfluidic-robotic interface for automated pipette-free high-precision liquid handling.
Lab on a chip
Oct 9, 2019
Microfluidic devices have been increasingly used for low-volume liquid handling operations. However, laboratory automation of such delicate devices has lagged behind due to the lack of world-to-chip (macro-to-micro) interfaces. In this paper, we have...
Recent Development of Computational Predicting Bioluminescent Proteins.
Current pharmaceutical design
Jan 1, 2019
Bioluminescent Proteins (BLPs) are widely distributed in many living organisms that act as a key role of light emission in bioluminescence. Bioluminescence serves various functions in finding food and protecting the organisms from predators. With the...
Enhancing fluorescent protein photostability through robot-assisted photobleaching.
Integrative biology : quantitative biosciences from nano to macro
Jul 16, 2018
Improving fluorescent proteins through the use of directed evolution requires robust techniques for screening large libraries of genetic variants. Here we describe an effective and relatively low-cost system for screening libraries of fluorescent pro...
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