Changes in stem cell activity may underpin aging. However, these changes are not completely understood. Here, we combined single-cell profiling with machine learning and in vivo functional studies to explore how hematopoietic stem cell (HSC) division...
Neuronal replacement therapies rely on the differentiation of specific cell types from embryonic or induced pluripotent stem cells, or on the direct reprogramming of differentiated adult cells via the expression of transcription factors or signaling...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2020
We present a fully closed-loop design for an artificial pancreas (AP) that regulates the delivery of insulin for the control of Type I diabetes. Our AP controller operates in a fully automated fashion, without requiring any manual interaction with th...
IEEE/ACM transactions on computational biology and bioinformatics
Dec 8, 2020
The prediction of epileptic seizures has been an essential problem of epilepsy study. The calcium imaging video data images the whole brain-wide neurons activities with electrical discharge recorded by calcium fluorescence intensity (CFI). In this pa...
BACKGROUND: The hallmark of myelodysplastic syndrome (MDS) remains dysplasia in the bone marrow (BM). However, diagnosing MDS may be challenging and subject to inter-observer variability. Thus, there is an unmet need for novel objective, standardized...
OBJECTIVE: To build the Wisconsin Stone Quality of Life Machine-Learning Algorithm (WISQOL-MLA) to predict urolithiasis patients' health-related quality of life (HRQoL) based on demographic, symptomatic and clinical data collected for the validation ...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Dec 7, 2020
Drugs in solid dispersion (SD) take advantage of fast and extended dissolution, thus attains a higher bioavailability than the crystal form. However, current development of SD relies on a random large-scale formulation screening method with low effic...
Cortical neurons process information on multiple timescales, and areas important for working memory (WM) contain neurons capable of integrating information over a long timescale. However, the underlying mechanisms for the emergence of neuronal timesc...
Journal of medical engineering & technology
Dec 7, 2020
It is estimated that missed opportunities for diagnosis occur in 1 in 20 primary care appointments. This is not only detrimental to individual patients, but also to the healthcare system as health outcomes are affected and healthcare expenditure inev...
PURPOSE: The finite element method (FEM) is the preferred method to simulate phenomena in anatomical structures. However, purely FEM-based mechanical simulations require considerable time, limiting their use in clinical applications that require real...
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