Ribonucleic Acid (RNA) is the central conduit for information transfer in the cell. Identifying potential RNA targets in disease conditions is a challenging task, given the vast repertoire of functional non-coding RNAs in a human cell. A potential dr...
In this issue of Molecular Cell, Schmid and Walter present "Predictomes," a machine-learning-based platform that utilizes AlphaFold-Multimer (AF-M) to identify high-confidence protein-protein interactions (PPIs). Their SPOC classifier is better than ...
Database : the journal of biological databases and curation
Mar 19, 2025
Federated learning is an upcoming machine learning paradigm which allows data from multiple sources to be used for training of classifiers without the data leaving the source it originally resides. This can be highly valuable for use cases such as me...
Recent advances in theoretical biology suggest that key definitions of basal cognition and sentient behavior may arise as emergent properties of in vitro cell cultures and neuronal networks. Such neuronal networks reorganize activity to demonstrate s...
The Journal of clinical endocrinology and metabolism
Mar 17, 2025
BACKGROUND: University Hospitals Dorset (UHD) has more than 1000 thyroid patient contacts annually. These are primarily patients with autoimmune hyperthyroidism treated with carbimazole titration. Dose adjustments are made by a healthcare professiona...
Targeted maximum likelihood estimation (TMLE) is an increasingly popular framework for the estimation of causal effects. It requires modeling both the exposure and outcome but is doubly robust in the sense that it is valid if at least one of these mo...
Protein structural fluctuations, measured by Debye-Waller factors or B-factors, are known to be closely associated with protein flexibility and function. Theoretical approaches have also been developed to predict B-factor values, which reflect protei...
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Mar 15, 2025
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment, yet their impact on bone health remains unclear. This study aimed to perform a retrospective cohort study utilizing routine CT scans from patients with melanoma to perform oppor...
Evolutionary Computation (EC) often throws away learned knowledge as it is reset for each new problem addressed. Conversely, humans can learn from small-scale problems, retain this knowledge (plus functionality), and then successfully reuse them in l...
BACKGROUND AND HYPOTHESIS: Substantive inquiry into the predictive power of eye movement (EM) features for clinical high-risk (CHR) conversion and their longitudinal trajectories is currently sparse. This study aimed to investigate the efficiency of ...
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