AIMC Topic: Mice
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Assessment of skin inflammation using near-infrared Raman spectroscopy combined with artificial intelligence analysis in an animal model.
The Analyst
Jun 13, 2022
Raman spectroscopy is a powerful method for estimating the molecular structure of a target that can be adapted for biomedical analysis given its non-destructive nature. Inflammatory skin diseases impair the skin's barrier function and interfere with ...
ZhenQi FuZheng formula inhibits the growth of colorectal tumors by modulating intestinal microflora-mediated immune function.
Aging
Jun 8, 2022
Zhenqi Fuzheng formula (ZQFZ), of which the main ingredients are and , has immune system regulatory functions and potential anti-tumor bioactivity. The inhibition of colorectal tumor growth by ZQFZ was analyzed in inflammatory cells and B6/JGpt-/Gpt...
CD147-specific chimeric antigen receptor T cells effectively inhibit T cell acute lymphoblastic leukemia.
Cancer letters
May 31, 2022
T cell acute lymphoblastic leukemia (T-ALL) is invasive and heterogeneous, and existing therapies are sometimes unsuccessful. Chimeric antigen receptor (CAR) T cell therapy is a breakthrough tumor treatment method, particularly for B cell acute lymph...
Magnetic-Powered Janus Cell Robots Loaded with Oncolytic Adenovirus for Active and Targeted Virotherapy of Bladder Cancer.
Advanced materials (Deerfield Beach, Fla.)
May 27, 2022
A unique robotic medical platform is designed by utilizing cell robots as the active "Trojan horse" of oncolytic adenovirus (OA), capable of tumor-selective binding and killing. The OA-loaded cell robots are fabricated by entirely modifying OA-infect...
Predicting and understanding arterial elasticity from key microstructural features by bidirectional deep learning.
Acta biomaterialia
May 25, 2022
Microstructural features and mechanical properties are closely related in all soft biological tissues. Both yet exhibit considerable inter-individual differences and are affected by factors such as aging and disease and its progression. Histological ...
Resolving complex cartilage structures in developmental biology via deep learning-based automatic segmentation of X-ray computed microtomography images.
Scientific reports
May 24, 2022
The complex shape of embryonic cartilage represents a true challenge for phenotyping and basic understanding of skeletal development. X-ray computed microtomography (μCT) enables inspecting relevant tissues in all three dimensions; however, most 3D m...
T cell immune responses deciphered.
Science (New York, N.Y.)
May 19, 2022
A machine-learning approach reveals antigen encoding that predicts T cell responses.
Machine learning sequence prioritization for cell type-specific enhancer design.
eLife
May 16, 2022
Recent discoveries of extreme cellular diversity in the brain warrant rapid development of technologies to access specific cell populations within heterogeneous tissue. Available approaches for engineering-targeted technologies for new neuron subtype...
Reversing radiation-induced immunosuppression using a new therapeutic modality.
Life sciences in space research
May 11, 2022
Radiation-induced immune suppression poses significant health challenges for millions of patients undergoing cancer chemotherapy and radiotherapy treatment, and astronauts and space tourists travelling to outer space. While a limited number of recomb...
Real-time 3D optoacoustic tracking of cell-sized magnetic microrobots circulating in the mouse brain vasculature.
Science advances
May 11, 2022
Mobile microrobots hold remarkable potential to revolutionize health care by enabling unprecedented active medical interventions and theranostics, such as active cargo delivery and microsurgical manipulations in hard-to-reach body sites. High-resolut...
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