. sleep staging is essential for diagnosing sleep disorders and managing sleep health. Traditional methods require time-consuming manual scoring. Recent photoplethysmography (PPG)-based deep learning models perform well on local datasets but struggle...
Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, but long-term immunosuppression (IS) is associated with significant side effects. Achieving operational tolerance (OT), where the graft is accepted without IS, remains...
BACKGROUND: Age-associated memory impairment (AAMI) is a predementia state linked to endothelial dysfunction. The endothelial activation and stress index (EASIX) quantifies endothelial injury, yet its association with cognitive function remains unval...
BACKGROUND: Evidence regarding the association between physical activity (PA) and diabetic retinopathy (DR) remains inconsistent. Furthermore, its effects on retinal vessel diameters in type 2 diabetes are not well established. We aimed to investigat...
Progress in neuro-psychopharmacology & biological psychiatry
Dec 4, 2025
PURPOSE: Metabolic disturbances are hallmark pathological features of Parkinson's disease (PD) and can be noninvasively captured by arterial spin labeling (ASL). However, the metabolic pattern of disconnections beyond regional alterations remains sca...
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with serious long-term effects if untreated, emphasizing the need for early treatment given its neurobiological heterogeneity. This study introduces a novel expla...
The interplay between diet and gut microbiome composition is complex. Faecal metabolites, the end products of human and microbial metabolism, provide insights into these interactions. Here, we integrate faecal metabolomics, metagenomics, and habitual...
BACKGROUND: Depressive episodes in bipolar disorder are frequent, prolonged, and contribute substantially to functional impairment and reduced quality of life. Therefore, early and objective detection of bipolar depression is critical for timely inte...
BACKGROUND: A high intake of dietary fiber has been shown to improve glycemic control and decrease hyperinsulinemia in people living with type 2 diabetes (T2D). T2D patients in Japan consume less than the recommended amount of fiber. Based on finding...
BACKGROUND: Large language models (LLMs) have rapidly advanced across numerous fields, including mental health care. A shortage of trained therapists and mental health care providers has driven informal use of LLMs for therapeutic support. However, t...
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