Guaranteeing clean drinking water to the global population is becoming more challenging, because of the cases of water scarcity across the globe, growing population, and increased chemical footprint of this population. Existing targeted strategies fo...
Assay interference compounds give rise to false-positives and cause substantial problems in medicinal chemistry. Nearly 500 compound classes have been designated as pan-assay interference compounds (PAINS), which typically occur as substructures in o...
The study is aimed at developing linear classifiers to predict the capacity of a given substrate to yield reactive metabolites. While most of the hitherto reported predictive models are based on the occurrence of known structural alerts (e.g., the pr...
Risk prediction modelling is important to better understand the determinants of the course and outcome of PBC and to inform the risk across the disease continuum in PBC enabling risk-stratified follow-up care and personalised therapy. Current prognos...
IEEE/ACM transactions on computational biology and bioinformatics
Nov 5, 2018
An important question in microbiology is whether treatment causes changes in gut flora, and whether it also affects metabolism. The reconstruction of causal relations purely from non-temporal observational data is challenging. We address the problem ...
Computational intelligence and neuroscience
Nov 5, 2018
The rapid development of modern communication technology makes the identification of emitter signals more complicated. Based on Ward's clustering and probabilistic neural networks method with correlation analysis, an ensemble identification algorithm...
IMPORTANCE: Forecasting the volume of hospital discharges has important implications for resource allocation and represents an opportunity to improve patient safety at periods of elevated risk.
Computer methods and programs in biomedicine
Oct 30, 2018
BACKGROUND AND OBJECTIVE: Computer aided detection (CAD) offers an efficient way to assist doctors to interpret fundus images. In a CAD system, retinal vessel (RV) detection is a crucial step to identify the retinal disease regions. However, RV detec...
OBJECTIVE: Metformin is the preferred first-line medication for management of type 2 diabetes and prediabetes. However, over a third of patients experience primary or secondary therapeutic failure. We developed machine learning models to predict whic...
Relation extraction between medical concepts from electronic medical records has pervasive applications as well as significance. However, previous researches utilizing machine learning algorithms judge the semantic types of medical concept pair menti...