AIMC Topic: Multiple Sclerosis, Chronic Progressive

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Relevance of choroid plexus volumes in multiple sclerosis.

Fluids and barriers of the CNS May 8, 2025
BACKGROUND: The choroid plexus (ChP) plays a pivotal role in inflammatory processes that occur in multiple sclerosis (MS). The enlargement of the ChP in relapsing-remitting multiple sclerosis (RRMS) is considered to be an indication of disease activi...
Female Adult Cross-Sectional Studies Male Humans White Matter Multiple Sclerosis, Relapsing-Remitting Middle Aged Multiple Sclerosis, Chronic Progressive Magnetic Resonance Imaging Choroid Plexus Multiple Sclerosis
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AI-assisted identification of disability patterns within identical EDSS grades.

Multiple sclerosis (Houndmills, Basingstoke, England) Apr 18, 2025
BACKGROUND: The Neurostatus-Expanded Disability Status Scale (EDSS) is the most frequently used measure of disability in multiple sclerosis (MS) trials. However, EDSS scores ⩾4.5 are mainly based on ambulation and may fail to capture relevant disabil...
Disability Evaluation Multiple Sclerosis, Chronic Progressive Artificial Intelligence Humans Machine Learning Middle Aged Female Adult Severity of Illness Index Male
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Estimating individual treatment effect on disability progression in multiple sclerosis using deep learning.

Nature communications Sep 26, 2022
Disability progression in multiple sclerosis remains resistant to treatment. The absence of a suitable biomarker to allow for phase 2 clinical trials presents a high barrier for drug development. We propose to enable short proof-of-concept trials by ...
Humans Recurrence Multiple Sclerosis, Relapsing-Remitting Disease Progression Multiple Sclerosis, Chronic Progressive Deep Learning Multiple Sclerosis
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Progressive Multiple Sclerosis Transcriptome Deconvolution Indicates Increased M2 Macrophages in Inactive Lesions.

European neurology Aug 28, 2020
Accumulating evidence suggests M2 macrophages contribute to tissue reparation and limit inflammation in multiple sclerosis (MS). However, most studies have focused on murine models without substantial support through human MS observations. The presen...
White Matter Multiple Sclerosis, Chronic Progressive Brain Female Adult Transcriptome Inflammation Male Middle Aged Humans Machine Learning Macrophages
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Occasional essay: Multiple sclerosis in the digital age: 'seeing through a glass darkly'.

Journal of neurology, neurosurgery, and psychiatry Jul 24, 2020
Artificial Intelligence Precision Medicine Genomics Magnetic Resonance Imaging Humans Knowledge Multiple Sclerosis, Relapsing-Remitting Multiple Sclerosis, Chronic Progressive Immunologic Factors Multiple Sclerosis Digital Technology
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Robot-assisted gait training is not superior to intensive overground walking in multiple sclerosis with severe disability (the RAGTIME study): A randomized controlled trial.

Multiple sclerosis (Houndmills, Basingstoke, England) Mar 4, 2019
BACKGROUND: Rehabilitation may attenuate the impact on mobility of patients with progressive multiple sclerosis (MS) and severe gait disabilities.
Walking Speed Gait Disorders, Neurologic Multiple Sclerosis, Chronic Progressive Middle Aged Follow-Up Studies Robotics Exercise Therapy Outcome Assessment, Health Care Single-Blind Method Humans Adult Walking Female Male
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The effectiveness of Robot-Assisted Gait Training versus conventional therapy on mobility in severely disabled progressIve MultiplE sclerosis patients (RAGTIME): study protocol for a randomized controlled trial.

Trials Feb 27, 2017
BACKGROUND: Gait and mobility impairments affect the quality of life (QoL) of patients with progressive multiple sclerosis (MS). Robot-assisted gait training (RAGT) is an effective rehabilitative treatment but evidence of its superiority compared to ...
Aged Single-Blind Method Young Adult Italy Recovery of Function Adult Walking Mobility Limitation Robotics Biomechanical Phenomena Exercise Tolerance Clinical Protocols Research Design Postural Balance Gait Muscle Fatigue Multiple Sclerosis, Chronic Progressive Treatment Outcome Biomarkers Exercise Therapy Disability Evaluation Surveys and Questionnaires Neuronal Plasticity Male Female Humans Adolescent Time Factors Muscle, Skeletal Middle Aged Persons with Disabilities Severity of Illness Index
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The effects of robot-assisted gait training in progressive multiple sclerosis: A randomized controlled trial.

Multiple sclerosis (Houndmills, Basingstoke, England) Dec 10, 2015
BACKGROUND: Gait and mobility impairments are common in progressive multiple sclerosis (MS), leading to reduced quality of life (QoL).
Robotics Single-Blind Method Male Exercise Therapy Exoskeleton Device Humans Multiple Sclerosis, Chronic Progressive Middle Aged Gait Disorders, Neurologic Quality of Life Female Adult
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