AIMC Topic: Myocardial Contraction

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Enhanced drug classification using machine learning with multiplexed cardiac contractility assays.

Pharmacological research
Cardiac screening of newly discovered drugs remains a longstanding challenge for the pharmaceutical industry. While therapeutic efficacy and cardiotoxicity are evaluated through preclinical biochemical and animal testing, 90 % of lead compounds fail ...

Rapid estimation of left ventricular contractility with a physics-informed neural network inverse modeling approach.

Artificial intelligence in medicine
Physics-based computer models based on numerical solutions of the governing equations generally cannot make rapid predictions, which in turn limits their applications in the clinic. To address this issue, we developed a physics-informed neural networ...

Soft robotic artificial left ventricle simulator capable of reproducing myocardial biomechanics.

Science robotics
The heart's intricate myocardial architecture has been called the Gordian knot of anatomy, an impossible tangle of intricate muscle fibers. This complexity dictates equally complex cardiac motions that are difficult to mimic in physical systems. If t...

Modeling 3D Cardiac Contraction and Relaxation With Point Cloud Deformation Networks.

IEEE journal of biomedical and health informatics
Global single-valued biomarkers, such as ejection fraction, are widely used in clinical practice to assess cardiac function. However, they only approximate the heart's true 3D deformation process, thus limiting diagnostic accuracy and the understandi...

Identifying high-risk Fontan phenotypes using K-means clustering of cardiac magnetic resonance-based dyssynchrony metrics.

Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
BACKGROUND: Individuals with a Fontan circulation encompass a heterogeneous group with adverse outcomes linked to ventricular dilation, dysfunction, and dyssynchrony. The purpose of this study was to assess if unsupervised machine learning cluster an...

Deep Learning-Derived Myocardial Strain.

JACC. Cardiovascular imaging
BACKGROUND: Echocardiographic strain measurements require extensive operator experience and have significant intervendor variability. Creating an automated, open-source, vendor-agnostic method to retrospectively measure global longitudinal strain (GL...

Deep learning-based framework for cardiac function assessment in embryonic zebrafish from heart beating videos.

Computers in biology and medicine
Zebrafish is a powerful and widely-used model system for a host of biological investigations, including cardiovascular studies and genetic screening. Zebrafish are readily assessable during developmental stages; however, the current methods for quant...