AIMC Topic: Neoplasms

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Federated Deep Learning Enables Cancer Subtyping by Proteomics.

Cancer discovery
UNLABELLED: Artificial intelligence applications in biomedicine face major challenges from data privacy requirements. To address this issue for clinically annotated tissue proteomic data, we developed a federated deep learning approach (ProCanFDL), t...

Whole Exome Sequencing on FHIR: Towards Adoption in Clinical Practice for Precision Oncology Pipelines.

Studies in health technology and informatics
INTRODUCTION: Whole Exome Sequencing (WES) promises to open a new range of personalized treatments due to breaking the limits of former panel-based methods of molecular analysis. While the methodology is well established and already included in clini...

Longitudinal evaluation of workflow optimization in radiotherapy: A 4-year retrospective study.

Journal of applied clinical medical physics
BACKGROUND: Efficient workflows are essential for timely, high-quality radiotherapy. In 2020, an internal audit identified key workflow bottlenecks, including long patient wait times, suboptimal treatment planning, and inadequate quality control. Acc...

The legend of the response evaluation criteria in solid tumors: A historical overview.

Cancer
METHODS: In this review, the historical development of tumor response criteria is examined and an interview was conducted with one of the original researchers behind the original study. This study, published nearly five decades ago, assessed tumor si...

Complexity-based unsupervised machine learning for patient-specific VMAT quality assurance.

Medical physics
BACKGROUND: Patient-specific quality assurance (PSQA) is essential to guarantee the requested accuracy and safety of high-precision radiotherapy treatments. With the widespread adoption of modulated-intensity techniques, there is a growing need for i...

Artificial Intelligence for Tumor [F]FDG PET Imaging: Advancements and Future Trends - Part II.

Seminars in nuclear medicine
The integration of artificial intelligence (AI) into [F]FDG PET/CT imaging continues to expand, offering new opportunities for more precise, consistent, and personalized oncologic evaluations. Building on the foundation established in Part I, this se...

An integrated approach for key gene selection and cancer phenotype classification: Improving diagnosis and prediction.

Computers in biology and medicine
The identification of key features and reliable phenotype classification remains pivotal in cancer research, with direct implications for early diagnosis, prognosis, treatment optimization, and cost reduction in healthcare. This study introduces a hy...

EnsemPred-ACP: Combining machine and deep learning to improve anticancer peptide prediction.

Computers in biology and medicine
Anticancer peptide (ACP) has emerged as potent therapeutic agents owing to its ability to selectively target cancer cells while minimising toxicity to healthy cells. However, the accurate computational prediction of ACP remains challenging because of...

Genetic features for drug responses in cancer - Investigating an ensemble-feature-selection approach.

Computers in biology and medicine
Predicting drug responses using genetic and transcriptomic features is crucial for enhancing personalized medicine. In this study, we implemented an ensemble of machine learning algorithms to analyze the correlation between genetic and transcriptomic...

Enhancing cancer diagnostics through a novel deep learning-based semantic segmentation algorithm: A low-cost, high-speed, and accurate approach.

Computers in biology and medicine
Deep learning-based semantic segmentation approaches provide an efficient and automated means for cancer diagnosis and monitoring, which is important in clinical applications. However, implementing these approaches outside the experimental environmen...