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Neural Inhibition

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Persistent irregular activity is a result of rebound and coincident detection mechanisms: A computational study.

Neural networks : the official journal of the International Neural Network Society
Persistent irregular activity is defined as elevated irregular neural discharges in the brain in such a way that while the average network activity displays high frequency oscillations, the participating neurons display irregular and low frequency os...

Tonic regulation of stationary asynchronous firing of a neural network.

Journal of computational neuroscience
The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA -receptors was found to control stationary asynchronous firing both quantitatively and qualitat...

Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.

Scientific reports
The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder ch...

Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.

Journal of computational neuroscience
It is believed that thalamic reticular nucleus (TRN) controls spindles and spike-wave discharges (SWD) in seizure or sleeping processes. The dynamical mechanisms of spatiotemporal evolutions between these two types of activity, however, are not well ...

Synchrony measure for a neuron driven by excitatory and inhibitory inputs and its adaptation to experimentally-recorded data.

Bio Systems
The aim of the current work is twofold: firstly to adapt an existing method measuring the input synchrony of a neuron driven only by excitatory inputs in such a way so as to account for inhibitory inputs as well and secondly to further appropriately ...

Mechanism-Based and Input-Output Modeling of the Key Neuronal Connections and Signal Transformations in the CA3-CA1 Regions of the Hippocampus.

Neural computation
This letter examines the results of input-output (nonparametric) modeling based on the analysis of data generated by a mechanism-based (parametric) model of CA3-CA1 neuronal connections in the hippocampus. The motivation is to obtain biological insig...

Effect of inhibitory spike-timing-dependent plasticity on fast sparsely synchronized rhythms in a small-world neuronal network.

Neural networks : the official journal of the International Neural Network Society
We consider the Watts-Strogatz small-world network (SWN) consisting of inhibitory fast spiking Izhikevich interneurons. This inhibitory neuronal population has adaptive dynamic synaptic strengths governed by the inhibitory spike-timing-dependent plas...

Global firing rate contrast enhancement in E/I neuronal networks by recurrent synchronized inhibition.

Chaos (Woodbury, N.Y.)
Inhibitory synchronization is commonly observed and may play some important functional roles in excitatory/inhibitory (E/I) neuronal networks. The firing rate contrast enhancement is a general feature of information processing in sensory pathways, an...

Neural network model of an amphibian ventilatory central pattern generator.

Journal of computational neuroscience
The neuronal multiunit model presented here is a formal model of the central pattern generator (CPG) of the amphibian ventilatory neural network, inspired by experimental data from Pelophylax ridibundus. The kernel of the CPG consists of three pacema...

Reducing variability in motor cortex activity at a resting state by extracellular GABA for reliable perceptual decision-making.

Journal of computational neuroscience
Interaction between sensory and motor cortices is crucial for perceptual decision-making, in which intracortical inhibition might have an important role. We simulated a neural network model consisting of a sensory network (N) and a motor network (N) ...