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Neurons

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Sparse connectivity enables efficient information processing in cortex-like artificial neural networks.

Frontiers in neural circuits
Neurons in cortical networks are very sparsely connected; even neurons whose axons and dendrites overlap are highly unlikely to form a synaptic connection. What is the relevance of such sparse connectivity for a network's function? Surprisingly, it h...

Unveiling CNS cell morphology with deep learning: A gateway to anti-inflammatory compound screening.

PloS one
Deciphering the complex relationships between cellular morphology and phenotypic manifestations is crucial for understanding cell behavior, particularly in the context of neuropathological states. Despite its importance, the application of advanced i...

Phase of firing does not reflect temporal order in sequence memory of humans and recurrent neural networks.

Nature neuroscience
The temporal order of a sequence of events has been thought to be reflected in the ordered firing of neurons at different phases of theta oscillations. Here we assess this by measuring single neuron activity (1,420 neurons) and local field potentials...

Interpretable deep learning for deconvolutional analysis of neural signals.

Neuron
The widespread adoption of deep learning to model neural activity often relies on "black-box" approaches that lack an interpretable connection between neural activity and network parameters. Here, we propose using algorithm unrolling, a method for in...

Ternary spike-based neuromorphic signal processing system.

Neural networks : the official journal of the International Neural Network Society
Deep Neural Networks (DNNs) have been successfully implemented across various signal processing fields, resulting in significant enhancements in performance. However, DNNs generally require substantial computational resources, leading to significant ...

Neurocounter - A deep learning framework for high-fidelity spatial localization of neurons.

Journal of neuroscience methods
BACKGROUND: Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology, and background artifacts. In addi...

Distributed Synaptic Connection Strength Changes Dynamics in a Population Firing Rate Model in Response to Continuous External Stimuli.

Neural computation
Neural network complexity allows for diverse neuronal population dynamics and realizes higherorder brain functions such as cognition and memory. Complexity is enhanced through chemical synapses with exponentially decaying conductance and greater vari...

Elucidating the Theoretical Underpinnings of Surrogate Gradient Learning in Spiking Neural Networks.

Neural computation
Training spiking neural networks to approximate universal functions is essential for studying information processing in the brain and for neuromorphic computing. Yet the binary nature of spikes poses a challenge for direct gradient-based training. Su...

The Leaky Integrate-and-Fire Neuron Is a Change-Point Detector for Compound Poisson Processes.

Neural computation
Animal nervous systems can detect changes in their environments within hundredths of a second. They do so by discerning abrupt shifts in sensory neural activity. Many neuroscience studies have employed change-point detection (CPD) algorithms to estim...

ASiDentify (ASiD): a machine learning model to predict new autism spectrum disorder risk genes.

Genetics
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects nearly 3% of children and has a strong genetic component. While hundreds of ASD risk genes have been identified through sequencing studies, the genetic heterogeneity of ASD ...