AIMC Topic: Ferritins

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Structural modification strategies for ferritin nanoparticles and their applications in biomedicine: a narrative review.

Nanoscale Jul 31, 2025
Ferritin is an iron-storage protein that naturally self-assembles into a hollow spherical particle consisting of 24 identical subunits, and it serves a central role in iron metabolism. Ferritin's favorable drug-loading capacity, biocompatibility, int...
Humans Drug Delivery Systems Animals Nanoparticles Metal Nanoparticles Neurodegenerative Diseases Ferritins
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Identification and Validation of Ferritinophagy-Related Biomarkers in Periodontitis.

International dental journal Apr 15, 2025
OBJECTIVE: While ferritinophagy is believed to play a significant role in the development of periodontitis, the exact mechanisms remain unclear. This study aimed to investigate the biomarkers associated with ferritinophagy in periodontitis using tran...
Humans Machine Learning Protein Interaction Maps Biomarkers Gene Regulatory Networks Periodontitis Gene Expression Profiling Ferritins Transcriptome
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Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy.

Journal of advanced research Sep 29, 2024
INTRODUCTION: Triple-negative breast cancer (TNBC) is the primary cause of breast cancer-induced death in women. Literature has confirmed the benefits of Salidroside (Sal) in treating TNBC. However, the study about potential therapeutic targets and m...
Triple Negative Breast Neoplasms Signal Transduction Mice, Nude Ferroptosis Female Animals Cell Line, Tumor Mice Xenograft Model Antitumor Assays Stearoyl-CoA Desaturase Lipogenesis Nuclear Receptor Coactivators Phenols Autophagy Glucosides Humans Ferritins
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Determination of prognostic markers for COVID-19 disease severity using routine blood tests and machine learning.

Anais da Academia Brasileira de Ciencias Jun 24, 2024
The need for the identification of risk factors associated to COVID-19 disease severity remains urgent. Patients' care and resource allocation can be potentially different and are defined based on the current classification of disease severity. This ...
Brazil Severity of Illness Index ROC Curve Ferritins Hematologic Tests Aged Adult Male Middle Aged Female SARS-CoV-2 Risk Factors Humans Machine Learning COVID-19 Biomarkers Prognosis
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Prognosis of COVID-19 severity using DERGA, a novel machine learning algorithm.

European journal of internal medicine Mar 8, 2024
It is important to determine the risk for admission to the intensive care unit (ICU) in patients with COVID-19 presenting at the emergency department. Using artificial neural networks, we propose a new Data Ensemble Refinement Greedy Algorithm (DERGA...
Female SARS-CoV-2 Aged Adult COVID-19 Algorithms Prognosis Intensive Care Units Ferritins L-Lactate Dehydrogenase Male Middle Aged Severity of Illness Index Neutrophils Humans Neural Networks, Computer Machine Learning
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Intravenous Iron Replacement Improves Exercise Tolerance in COPD: A Single-Blind Randomized Trial.

Archivos de bronconeumologia Sep 3, 2021
INTRODUCTION: Iron deficiency affects exercise capacity because of the critical role iron plays in the optimal functioning of skeletal muscle metabolism. We hypothesized that intravenous iron may improve exercise tolerance, quality of life (QoL), and...
Anemia, Iron-Deficiency Treatment Outcome Maltose Humans Exercise Tolerance Single-Blind Method Transferrins Pulmonary Disease, Chronic Obstructive Ferric Compounds Iron Quality of Life Iron Deficiencies Ferritins
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Label-free approach for electrochemical ferritin sensing using biosurfactant stabilized tungsten disulfide quantum dots.

Biosensors & bioelectronics Dec 21, 2019
A novel approach for the synthesis of biosurfactant stabilized/functionalized tungsten disulfide (WS-B) quantum dots (QDs) and its application for ferritin immunosensor is reported. These 2-D layered material derived quantum dots are synthesized via ...
Disulfides Tungsten Quantum Dots Humans Electrochemical Techniques Biosensing Techniques Ferritins
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Novel Iron-Whey Protein Microspheres Protect Gut Epithelial Cells from Iron-Related Oxidative Stress and Damage and Improve Iron Absorption in Fasting Adults.

Acta haematologica Jan 5, 2018
BACKGROUND: Iron food fortification and oral iron formulations are frequently limited by poor absorption, resulting in the widespread use of high-dose oral iron, which is poorly tolerated.
Intestinal Absorption Cross-Over Studies Iron Deficiencies Humans Microspheres Oxidative Stress Prospective Studies Whey Proteins Epithelial Cells Double-Blind Method Female Protective Agents Iron Adult Drug Carriers Ferritins Male Fasting
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Using machine learning to predict laboratory test results.

Annals of clinical biochemistry Aug 19, 2016
Humans Machine Learning Biomarkers Decision Support Systems, Clinical Iron Ferritins Anemia, Iron-Deficiency
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Using Machine Learning to Predict Laboratory Test Results.

American journal of clinical pathology Jun 21, 2016
OBJECTIVES: While clinical laboratories report most test results as individual numbers, findings, or observations, clinical diagnosis usually relies on the results of multiple tests. Clinical decision support that integrates multiple elements of labo...
Middle Aged Decision Support Systems, Clinical Ferritins Female Humans Aged Machine Learning Adult Algorithms Male Decision Support Techniques
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