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Prostatic Neoplasms

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Deep Learning-Based Tumor Segmentation of Murine Magnetic Resonance Images of Prostate Cancer Patient-Derived Xenografts.

Tomography (Ann Arbor, Mich.)
BACKGROUND/OBJECTIVE: Longitudinal in vivo studies of murine xenograft models are widely utilized in oncology to study cancer biology and develop therapies. Magnetic resonance imaging (MRI) of these tumors is an invaluable tool for monitoring tumor g...

Clinical implications of deep learning based image analysis of whole radical prostatectomy specimens.

Scientific reports
Prostate cancer (PCa) diagnosis faces significant challenges due to its complex pathological characteristics and insufficient pathologist resources. While deep learning-based image analysis (DLIA) shows promise in enhancing diagnostic accuracy, its a...

Machine learning models for enhanced diagnosis and risk assessment of prostate cancer with Ga-PSMA-617 PET/CT.

European journal of radiology
OBJECTIVE: Prostate cancer (PCa) is highly heterogeneous, making early detection of adverse pathological features crucial for improving patient outcomes. This study aims to predict PCa aggressiveness and identify radiomic and protein biomarkers assoc...

Deep learning techniques for proton dose prediction across multiple anatomical sites and variable beam configurations.

Physics in medicine and biology
To evaluate the impact of beam mask implementation and data aggregation on artificial intelligence-based dose prediction accuracy in proton therapy, with a focus on scenarios involving limited or highly heterogeneous datasets.In this study, 541 prost...

Requirements for AI Development and Reporting for MRI Prostate Cancer Detection in Biopsy-Naive Men: PI-RADS Steering Committee, Version 1.0.

Radiology
This document defines the key considerations for developing and reporting an artificial intelligence (AI) interpretation model for the detection of clinically significant prostate cancer (PCa) at MRI in biopsy-naive men with a positive clinical scree...

Integrating machine learning driven virtual screening and molecular dynamics simulations to identify potential inhibitors targeting PARP1 against prostate cancer.

Scientific reports
Prostate cancer (PC) is one of the most common types of malignancies in men, with a noteworthy increase in newly diagnosed cases in recent years. PARP1 is a ubiquitous nuclear enzyme involved in DNA repair, nuclear transport, ribosome synthesis, and ...

A machine learning toolkit assisted approach for IMRT fluence map optimization: feasibility and advantages.

Biomedical physics & engineering express
. Traditional machine learning (ML) and deep learning (DL) applications in treatment planning rely on complex model architectures and large, high-quality training datasets. However, they cannot fully replace the conventional optimization process. Thi...

Predicting Prostate Cancer Diagnosis Using Machine Learning Analysis of Healthcare Utilization Patterns.

Studies in health technology and informatics
This study investigated healthcare utilization patterns prior to prostate cancer diagnoses, aiming to develop machine learning models for early prediction of cancer diagnosis. Data from the All of Us Research Program was used, focusing on adult patie...

Development and validation of a framework for registration of whole-mount radical prostatectomy histopathology with three-dimensional transrectal ultrasound.

BMC urology
PURPOSE: Artificial intelligence (AI) has the potential to improve diagnostic imaging on multiple levels. To develop and validate these AI-assisted modalities a reliable dataset is of utmost importance. The registration of imaging to pathology is an ...