AIMC Topic: Protein Aggregates
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Artificial intelligence assisted identification of potential tau aggregation inhibitors: ligand- and structure-based virtual screening, in silico ADME, and molecular dynamics study.
Molecular diversity
Apr 6, 2023
Alzheimer's disease (AD) is a severe, growing, multifactorial disorder affecting millions of people worldwide characterized by cognitive decline and neurodegeneration. The accumulation of tau protein into paired helical filaments is one of the major ...
Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy.
Pharmaceutical research
Jan 26, 2022
OBJECTIVE: Digital microscopy is used to monitor particulates such as protein aggregates within biopharmaceutical products. The images that result encode a wealth of information that is underutilized in pharmaceutical process monitoring. For example,...
New Frontiers for Machine Learning in Protein Science.
Journal of molecular biology
Sep 6, 2021
Protein function is fundamentally reliant on inter-molecular interactions that underpin the ability of proteins to form complexes driving biological processes in living cells. Increasingly, such interactions are recognised as being formed between pro...
An apta-aggregation based machine learning assay for rapid quantification of lysozyme through texture parameters.
PloS one
Mar 8, 2021
A novel assay technique that involves quantification of lysozyme (Lys) through machine learning is put forward here. This article reports the tendency of the well- documented Ellington group anti-Lys aptamer, to produce aggregates when exposed to Lys...
Machine learning and statistical analyses for extracting and characterizing "fingerprints" of antibody aggregation at container interfaces from flow microscopy images.
Biotechnology and bioengineering
Jul 28, 2020
Therapeutic proteins are exposed to numerous stresses during their manufacture, shipping, storage and administration to patients, causing them to aggregate and form particles through a variety of different mechanisms. These varied mechanisms generate...
The Classifying Autoencoder: Gaining Insight into Amyloid Assembly of Peptides and Proteins.
The journal of physical chemistry. B
Jun 13, 2019
Despite the importance of amyloid formation in disease pathology, the understanding of the primary structure?activity relationship for amyloid-forming peptides remains elusive. Here we use a new neural-network based method of analysis: the classifyin...
Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations.
Journal of pharmaceutical sciences
Oct 27, 2018
Current technologies for monitoring the subvisible particles that may be generated during fill-finish operations for protein formulations are cumbersome. Measurement times are generally too long for real-time analysis, and the high protein concentrat...
The Rational Discovery of a Tau Aggregation Inhibitor.
Biochemistry
Oct 5, 2018
Intrinsically disordered proteins play vital roles in biology, and their dysfunction contributes to many major disease states. These proteins remain challenging targets for rational ligand discovery or drug design because they are highly dynamic and ...
Stability of infliximab solutions in different temperature and dilution conditions.
Journal of pharmaceutical and biomedical analysis
Dec 18, 2017
Infliximab is a monoclonal antibody widely used for the treatment of inflammatory diseases. Over the past few years, many studies have assessed that monoclonal antibodies are prone to aggregation under stress conditions. The aim of this study was to ...
Biosimilar Pharmaceuticals
Protein Stability
Drug Stability
Pharmaceutical Solutions
Technology, Pharmaceutical
Drug Compounding
Osmolar Concentration
Nanoparticles
Peptide Mapping
Spectroscopy, Fourier Transform Infrared
Infliximab
Chromatography, Gel
Temperature
Antirheumatic Agents
Chromatography, Ion Exchange
Time Factors
Protein Aggregates
Nephelometry and Turbidimetry
Spectrophotometry, Ultraviolet
Protective effect of Nelumbo nucifera extracts on beta amyloid protein induced apoptosis in PC12 cells, in vitro model of Alzheimer's disease.
Journal of food and drug analysis
Mar 17, 2017
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. β-Amyloid (Aβ) has been proposed to play a role in the pathogenesis of AD. Deposits of insoluble Aβ are found in the brains of patients with AD and are one of the pathologi...
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