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Randomized Controlled Trials as Topic

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Using artificial intelligence to semi-automate trustworthiness assessment of randomized controlled trials: a case study.

Journal of clinical epidemiology
BACKGROUND AND OBJECTIVE: Randomized controlled trials (RCTs) are the cornerstone of evidence-based medicine. Unfortunately, not all RCTs are based on real data. This serious breach of research integrity compromises the reliability of systematic revi...

Comparative efficacy of robot-assisted therapy associated with other different interventions on upper limb rehabilitation after stroke: A protocol for a network meta-analysis.

PloS one
INTRODUCTION: Post-stroke movement disorders are common, especially upper limb dysfunction, which seriously affects the physical and mental health of stroke patients. With the continuous development of intelligent technology, robot-assisted therapy h...

Comparison of Different Machine Learning Methodologies for Predicting the Non-Specific Treatment Response in Placebo Controlled Major Depressive Disorder Clinical Trials.

Clinical and translational science
Placebo effect represents a serious confounder for the assessment of treatment effect to the extent that it has become increasingly difficult to develop antidepressant medications appropriate for outperforming placebo. Treatment effect in randomized,...

Evaluating generalizability of oncology trial results to real-world patients using machine learning-based trial emulations.

Nature medicine
Randomized controlled trials (RCTs) evaluating anti-cancer agents often lack generalizability to real-world oncology patients. Although restrictive eligibility criteria contribute to this issue, the role of selection bias related to prognostic risk r...

Machine-learning approaches to predict individualized treatment effect using a randomized controlled trial.

European journal of epidemiology
Recent advancements in machine learning (ML) for analyzing heterogeneous treatment effects (HTE) are gaining prominence within the medical and epidemiological communities, offering potential breakthroughs in the realm of precision medicine by enablin...

ChatGPT-4 Performance on German Continuing Medical Education-Friend or Foe (Trick or Treat)? Protocol for a Randomized Controlled Trial.

JMIR research protocols
BACKGROUND: The increasing development and spread of artificial and assistive intelligence is opening up new areas of application not only in applied medicine but also in related fields such as continuing medical education (CME), which is part of the...

AI-driven evidence synthesis: data extraction of randomized controlled trials with large language models.

International journal of surgery (London, England)
The advancement of large language models (LLMs) presents promising opportunities to enhance evidence synthesis efficiency, particularly in data extraction processes, yet existing prompts for data extraction remain limited, focusing primarily on commo...