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Effect of ethanol extract of nigella sativa L seeds and propofol on BDNF protein level as neuroplasticity and neuroprotection of traumatic brain injury in rats.

F1000Research
BACKGROUND: Traumatic brain injury (TBI) is a change in brain function or evidence of brain pathology caused by external mechanical forces. Brain Derived Neurotrophic Factor (BDNF) is a neurotropin that functions as a neuron protective. Nigella sativ...

The Bioprotective Effects of Marigold Tea Polyphenols on Obesity and Oxidative Stress Biomarkers in High-Fat-Sugar Diet-Fed Rats.

Cardiovascular therapeutics
The research is aimed at exploring the potential of marigold petal tea (MPT), rich in polyphenol contents, against oxidative stress and obesity in a rat model following a high-fat-sugar diet (HFSD). The MPT was prepared through the customary method...

Severe degranulation of mesenteric mast cells in an experimental rat mammary tumor model.

Turkish journal of medical sciences
BACKGROUND/AIM: Breast cancers are one of the most common cancers in women and are responsible for many deaths worldwide. Mast cells are inflammatory cells. Their role in cancers is controversial, and there is limited data on systemic mast cell activ...

Cytotoxicity, Antiadipogenic, Low-Density Lipoprotein Oxidation Inhibitory Activities, and Acute Toxicity Study of Hydroethanolic Leaf and Bark Extracts.

TheScientificWorldJournal
Obesity is increasingly taking an important stage as a cause of death worldwide, and interventions with a good cost-effectiveness ratio are needed. is one of these natural products with health benefits. Objective. The present study evaluated the cy...

Photonic platform coupled with machine learning algorithms to detect pyrolysis products of crack cocaine in saliva: A proof-of-concept animal study.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
The non-invasive detection of crack/cocaine and other bioactive compounds from its pyrolysis in saliva can provide an alternative for drug analysis in forensic toxicology. Therefore, a highly sensitive, fast, reagent-free, and sustainable approach wi...

Immunohistochemistry-Free Enhanced Histopathology of the Rat Spleen Using Deep Learning.

Toxicologic pathology
Enhanced histopathology of the immune system uses a precise, compartment-specific, and semi-quantitative evaluation of lymphoid organs in toxicology studies. The assessment of lymphocyte populations in tissues is subject to sampling variability and l...

Development of a Deep Learning Tool to Support the Assessment of Thyroid Follicular Cell Hypertrophy in the Rat.

Toxicologic pathology
Thyroid tissue is sensitive to the effects of endocrine disrupting substances, and this represents a significant health concern. Histopathological analysis of tissue sections of the rat thyroid gland remains the gold standard for the evaluation for a...

Rapid detection of drug abuse via tear analysis using surface enhanced Raman spectroscopy and machine learning.

Scientific reports
With the growing global challenge of drug abuse, there is an urgent need for rapid, accurate, and cost-effective drug detection methods. This study introduces an innovative approach to drug abuse screening by quickly detecting ephedrine (EPH) in tear...

Replay as a Basis for Backpropagation Through Time in the Brain.

Neural computation
How episodic memories are formed in the brain is a continuing puzzle for the neuroscience community. The brain areas that are critical for episodic learning (e.g., the hippocampus) are characterized by recurrent connectivity and generate frequent off...

Analysis of Operant Self-administration Behaviors with Supervised Machine Learning: Protocol for Video Acquisition and Pose Estimation Analysis Using DeepLabCut and Simple Behavioral Analysis.

eNeuro
The use of supervised machine learning to approximate poses in video recordings allows for rapid and efficient analysis of complex behavioral profiles. Currently, there are limited protocols for automated analysis of operant self-administration behav...