AIMC Topic: Recombinant Proteins
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The potential of random forest and neural networks for biomass and recombinant protein modeling in Escherichia coli fed-batch fermentations.
Biotechnology journal
Aug 11, 2015
Product quality assurance strategies in production of biopharmaceuticals currently undergo a transformation from empirical "quality by testing" to rational, knowledge-based "quality by design" approaches. The major challenges in this context are the ...
A deep learning model trained on expressed transcripts across different tissue types reveals cell-type codon-optimization preferences.
Nucleic acids research
Mar 20, 2025
Species-specific differences in protein translation can affect the design of protein-based drugs. Consequently, efficient expression of recombinant proteins often requires codon optimization. Publicly available optimization tools do not always result...
Machine learning modeling of the effects of media formulated with various yeast extracts on heterologous protein production in Escherichia coli.
MicrobiologyOpen
Jun 1, 2021
In microbial manufacturing, yeast extract is an important component of the growth media. The production of heterologous proteins often varies because of the yeast extract composition. To identify why this reduces protein production, the effects of ye...
GOF/LOF knowledge inference with tensor decomposition in support of high order link discovery for gene, mutation and disease.
Mathematical biosciences and engineering : MBE
Feb 20, 2019
For discovery of new usage of drugs, the function type of their target genes plays an important role, and the hypothesis of "Antagonist-GOF" and "Agonist-LOF" has laid a solid foundation for supporting drug repurposing. In this research, an active ge...
[rhPDGF-BB promotes migration of bone marrow stromal stem cells in diabetic rats].
Shanghai kou qiang yi xue = Shanghai journal of stomatology
Dec 1, 2018
PURPOSE: To evaluate the effect of different concentrations of rhPDGF-BB on bone marrow stromal stem cells(BMSCs) migration in diabetic rat, and related mechanisms of SDF-1 and its G-protein conjugated receptor regulation, provide a theoretical basis...
[Single-chain antibodies from alpaca for the detection of Fasciola hepatica antigens].
Revista peruana de medicina experimental y salud publica
Jan 1, 2018
OBJECTIVES.: To produce recombinant single-chain antibodies from alpaca that will bind to the excreted-secreted (ES) Fasciola hepatica antigen with high affinity and specificity, so as to develop new diagnostic technologies of human and animal fascio...
[Construction and high-density fermentation of alkaline pectate lyase high-yield yeast].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Dec 25, 2017
Pectate lyase is widely applied in ramie degumming and fabric bioscouring in the textile industry. Compared to conventional processes that involve high alkaline and high temperature treatment, enzyme based treatments have significant advantages in fi...
Prokaryotic Expression of Hepatitis C Virus-NS3 Protein and Preparation of a Monoclonal Antibody.
Monoclonal antibodies in immunodiagnosis and immunotherapy
Dec 1, 2017
Hepatitis C virus (HCV) is a significant health threat that has been extensively investigated worldwide. Improving the sensitivity and specificity of laboratory tests for screening and early diagnosis of HCV in a relevant population is an effective m...
[Effect of Recombinant Antigen Ferritin on DC Induce Immune Response].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Nov 1, 2017
OBJECTIVE: To explore the immunoreaction against protoscolex infection by the recombinant ferritin of echinococcus granulosus (rEg.ferritin) immunized mice.
Cost-effective batch production process of scFv antibody in Escherichia coli.
Human antibodies
Jan 1, 2017
BACKGROUND: Cost-effective production of antibody (Ab) fragments is of great interests of many pharmaceutical industries, in large part due to their high usages in research, diagnosis and therapy. Thus, the production of Abs necessitates accomplishme...
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