AIMC Topic: Severity of Illness Index
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Gut microbiota alterations are linked to COVID-19 severity in North African and European populations.
NPJ biofilms and microbiomes
Jun 13, 2025
Although COVID-19 primarily affects the respiratory system, many patients experience gastrointestinal symptoms, suggesting a role for the gut microbiota in disease pathogenesis. To explore this, we performed shotgun metagenomic sequencing on stool sa...
Real-world effectiveness of cariprazine in major depressive disorder and bipolar I disorder in the United States.
Journal of medical economics
Jun 10, 2025
AIMS: The efficacy of cariprazine for major depressive disorder (MDD) (adjunctive therapy) and bipolar I (BP-I) depression has been demonstrated in clinical trials. This study evaluated the real-world effectiveness of cariprazine in reducing depressi...
Mortality Prediction Performance Under Geographical, Temporal, and COVID-19 Pandemic Dataset Shift: External Validation of the Global Open-Source Severity of Illness Score Model.
Critical care explorations
Jun 4, 2025
BACKGROUND: Risk-prediction models are widely used for quality of care evaluations, resource management, and patient stratification in research. While established models have long been used for risk prediction, healthcare has evolved significantly, a...
Artificial intelligence-based Raynaud's quantification index (ARTIX): an objective mobile-based tool for patient-centered assessment of Raynaud's phenomenon.
Arthritis research & therapy
Jun 3, 2025
BACKGROUND: We aimed to develop an artificial intelligence algorithm able to assess Raynaud's phenomenon (RP) from mobile phone photography, ensuring as a patient-centered, image-based method for RP quantification.
Using machine learning to identify Parkinson's disease severity subtypes with multimodal data.
Journal of neuroengineering and rehabilitation
Jun 2, 2025
BACKGROUND: Classifying and predicting Parkinson's disease (PD) is challenging because of its diverse subtypes based on severity levels. Currently, identifying objective biomarkers associated with disease severity that can distinguish PD subtypes in ...
Estimating motor symptom presence and severity in Parkinson's disease from wrist accelerometer time series using ROCKET and InceptionTime.
Scientific reports
May 31, 2025
Parkinson's disease (PD) is a neurodegenerative condition characterized by frequently changing motor symptoms, necessitating continuous symptom monitoring for more targeted treatment. Classical time series classification and deep learning techniques ...
Clinical, genetic, and sociodemographic predictors of symptom severity after internet-delivered cognitive behavioural therapy for depression and anxiety.
BMC psychiatry
May 30, 2025
BACKGROUND: Internet-delivered cognitive behavioural therapy (ICBT) is an effective and accessible treatment for mild to moderate depression and anxiety disorders. However, up to 50% of patients do not achieve sufficient symptom relief. Identifying p...
A data-centric and interpretable EEG framework for depression severity grading using SHAP-based insights.
Journal of neuroengineering and rehabilitation
May 25, 2025
BACKGROUND: Major Depressive Disorder is a leading cause of disability worldwide. An accurate assessment of depression severity is critical for diagnosis, treatment planning, and monitoring, yet current clinical tools are largely subjective, relying ...
Development of a risk prediction model for secondary infection in severe/critical COVID-19 patients.
BMC infectious diseases
May 21, 2025
OBJECTIVE: This study aimed to develop a predictive model for secondary infections in patients with severe or critical COVID-19 by analyzing clinical characteristics and laboratory indicators.
Metabolic signature of COVID-19 progression: potential prognostic markers for severity and outcome.
Metabolomics : Official journal of the Metabolomic Society
May 21, 2025
INTRODUCTION: There are significant challenges remain in accurately categorizing the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients.
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