AIMC Topic: Shock, Hemorrhagic

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Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.

Science translational medicine May 28, 2025
Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into the circulation, referred to as the systemic storm. The systemic storm drives the systemic inflammatory response and is associated with increased morta...
Sex Characteristics Sex Factors Hemorrhage Female Mice, Inbred C57BL Mice, Knockout Animals Intracellular Signaling Peptides and Proteins Mice Phosphate-Binding Proteins Apoptosis Gasdermins Male Humans Wounds and Injuries Shock, Hemorrhagic
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Advanced medical monitoring for the battlefield: A review on clinical applicability of compensatory reserve measurements for early and accurate hemorrhage detection.

The journal of trauma and acute care surgery Mar 8, 2022
Hemorrhagic shock remains the leading cause of mortality in civilian trauma and battlefield settings. The ability of combat medics and other military medical personnel to obtain early identification and assessment of a bleeding casualty is hampered b...
Humans Artificial Intelligence Resuscitation Shock, Hemorrhagic Monitoring, Physiologic Hemorrhage
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Abdominal compartment syndrome in traumatic hemorrhagic shock: is there a fluid resuscitation inflection point associated with increased risk?

American journal of surgery Dec 31, 2015
BACKGROUND: The volume of fluid administered during trauma resuscitation correlates with the risk of abdominal compartment syndrome (ACS). The exact volume at which this risk rises is uncertain. We established the inflection point for ACS risk during...
Fluid Therapy Risk Factors United States Shock, Hemorrhagic Adult Treatment Outcome International Normalized Ratio Wounds, Nonpenetrating Length of Stay Humans Compartment Syndromes Injury Severity Score Female Abdomen Male Retrospective Studies Lactates
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A New Time-Window Prediction Model For Traumatic Hemorrhagic Shock Based on Interpretable Machine Learning.

Shock (Augusta, Ga.) Jan 1, 2022
Early warning prediction of traumatic hemorrhagic shock (THS) can greatly reduce patient mortality and morbidity. We aimed to develop and validate models with different stepped feature sets to predict THS in advance. From the PLA General Hospital Eme...
Humans Machine Learning Middle Aged Logistic Models Aged Blood Gas Analysis Algorithms Vital Signs Adult Female Shock, Hemorrhagic Male
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Clinical decision support for severe trauma patients: Machine learning based definition of a bundle of care for hemorrhagic shock and traumatic brain injury.

The journal of trauma and acute care surgery Jan 1, 2022
BACKGROUND: Deviation from guidelines is frequent in emergency situations, and this may lead to increased mortality. Probably because of time constraints, 55% is the greatest reported guidelines compliance rate in severe trauma patients. This study a...
Critical Care Quality Improvement Practice Guidelines as Topic Registries Patient Care Bundles Trauma Severity Indices France Shock, Hemorrhagic Hospital Mortality Decision Support Systems, Clinical Brain Injuries, Traumatic Emergency Medical Services Guideline Adherence Female Adult Humans Male Machine Learning
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Detecting central hypovolemia in simulated hypovolemic shock by automated feature extraction with principal component analysis.

Physiological reports Nov 1, 2018
Assessment of the volume status by blood pressure (BP) monitoring is difficult, since baroreflex control of BP makes it insensitive to blood loss up to about one liter. We hypothesized that a machine learning model recognizes the progression of centr...
Hypovolemia Shock, Hemorrhagic Lower Body Negative Pressure Humans Female Machine Learning Principal Component Analysis Adult Blood Pressure Male
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