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LS-GKM: a new gkm-SVM for large-scale datasets.

Bioinformatics (Oxford, England) Mar 15, 2016
UNLABELLED: gkm-SVM is a sequence-based method for predicting and detecting the regulatory vocabulary encoded in functional DNA elements, and is a commonly used tool for studying gene regulatory mechanisms. Here we introduce new software, LS-GKM, whi...
Gene Regulatory Networks Support Vector Machine DNA Humans Software Chromatin Immunoprecipitation
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GOexpress: an R/Bioconductor package for the identification and visualisation of robust gene ontology signatures through supervised learning of gene expression data.

BMC bioinformatics Mar 11, 2016
BACKGROUND: Identification of gene expression profiles that differentiate experimental groups is critical for discovery and analysis of key molecular pathways and also for selection of robust diagnostic or prognostic biomarkers. While integration of ...
Computational Biology RNA, Messenger Software Supervised Machine Learning Transcriptome Gene Ontology
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An Efficacious Multi-Objective Fuzzy Linear Programming Approach for Optimal Power Flow Considering Distributed Generation.

PloS one Mar 8, 2016
This paper proposes a new formulation for the multi-objective optimal power flow (MOOPF) problem for meshed power networks considering distributed generation. An efficacious multi-objective fuzzy linear programming optimization (MFLP) algorithm is pr...
Algorithms Software Models, Theoretical Fuzzy Logic
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The First Interlaced Continuum Robot, Devised to Intrinsically Follow the Leader.

PloS one Feb 25, 2016
Flexible probes that are safely deployed to hard-to-reach targets while avoiding critical structures are strategic in several high-impact application fields, including the biomedical sector and the sector of inspections at large. A critical problem f...
Software Robotics Robotic Surgical Procedures
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Symmetry Analysis of Gait between Left and Right Limb Using Cross-Fuzzy Entropy.

Computational and mathematical methods in medicine Feb 24, 2016
The purpose of this paper is the investigation of gait symmetry problem by using cross-fuzzy entropy (C-FuzzyEn), which is a recently proposed cross entropy that has many merits as compared to the frequently used cross sample entropy (C-SampleEn). Fi...
Fuzzy Logic Parkinson Disease Models, Statistical Case-Control Studies ROC Curve Aged Support Vector Machine Computer Simulation Sensitivity and Specificity Young Adult Humans Female Adult Male Software Gait Reproducibility of Results Middle Aged Algorithms Extremities
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Mixed Integer Linear Programming based machine learning approach identifies regulators of telomerase in yeast.

Nucleic acids research Feb 22, 2016
Understanding telomere length maintenance mechanisms is central in cancer biology as their dysregulation is one of the hallmarks for immortalization of cancer cells. Important for this well-balanced control is the transcriptional regulation of the te...
Nuclear Proteins Mutation Sirtuin 2 Software Reproducibility of Results Gene Regulatory Networks Repressor Proteins Saccharomyces cerevisiae Proteins Mediator Complex Programming, Linear Saccharomyces cerevisiae Gene Expression Regulation, Fungal Histones Machine Learning Telomerase
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Predicting lysine phosphoglycerylation with fuzzy SVM by incorporating k-spaced amino acid pairs into Chou׳s general PseAAC.

Journal of theoretical biology Feb 22, 2016
As a new type of post-translational modification, lysine phosphoglycerylation plays a key role in regulating glycolytic process and metabolism in cells. Due to the traditional experimental methods are time-consuming and labor-intensive, it is importa...
Diphosphoglyceric Acids Fuzzy Logic Protein Processing, Post-Translational Amino Acids Amino Acid Sequence Software Reproducibility of Results Lysine Algorithms Computational Biology Binding Sites Support Vector Machine
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OntoCR: A CEN/ISO-13606 clinical repository based on ontologies.

Journal of biomedical informatics Feb 18, 2016
OBJECTIVE: To design a new semantically interoperable clinical repository, based on ontologies, conforming to CEN/ISO 13606 standard.
Semantics Systematized Nomenclature of Medicine Biological Ontologies Systems Integration Forms and Records Control Humans Internet Programming Languages Information Storage and Retrieval Software Algorithms Electronic Health Records
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Single-Cell Phenotype Classification Using Deep Convolutional Neural Networks.

Journal of biomolecular screening Feb 12, 2016
Deep learning methods are currently outperforming traditional state-of-the-art computer vision algorithms in diverse applications and recently even surpassed human performance in object recognition. Here we demonstrate the potential of deep learning ...
Machine Learning Software Algorithms Support Vector Machine Humans Single-Cell Analysis Neural Networks, Computer Image Processing, Computer-Assisted
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Comparison of Planning Quality and Efficiency Between Conventional and Knowledge-based Algorithms in Nasopharyngeal Cancer Patients Using Intensity Modulated Radiation Therapy.

International journal of radiation oncology, biology, physics Feb 12, 2016
PURPOSE: Intensity modulated radiation therapy (IMRT) is widely used to achieve a highly conformal dose and improve treatment outcome. However, plan quality and planning time are institute and planner dependent, and no standardized tool exists to rec...
Sensitivity and Specificity User-Computer Interface Treatment Outcome Workload Knowledge Bases Radiotherapy Planning, Computer-Assisted Humans Software Reproducibility of Results Software Validation Radiotherapy, Conformal Radiotherapy Dosage Nasopharyngeal Neoplasms
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