AIMC Topic: Spectrometry, Mass, Electrospray Ionization
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HPLC-MS/MS method for the determination and pharmacokinetic study of six compounds against rheumatoid arthritis in rat plasma after oral administration of the extract of Caulophyllum robustum Maxim.
Journal of pharmaceutical and biomedical analysis
Oct 21, 2019
Caulophyllum robustum Maxim (CRM) is a well-known traditional Chinese medicine (TCM) mainly present in the northeast, northwest and southwest regions of China, which is belong to the family Berberidaceae. The roots and rhizomes of CRM have been used ...
Trace, Machine Learning of Signal Images for Trace-Sensitive Mass Spectrometry: A Case Study from Single-Cell Metabolomics.
Analytical chemistry
Apr 15, 2019
Recent developments in high-resolution mass spectrometry (HRMS) technology enabled ultrasensitive detection of proteins, peptides, and metabolites in limited amounts of samples, even single cells. However, extraction of trace-abundance signals from c...
Decomposition Kinetics of Omethoate in Blood.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To study the decomposition kinetics of omethoate in blood.
Determination of Oleandrin in Blood and Liver Samples by LC-MS/MS.
Fa yi xue za zhi
Dec 25, 2018
OBJECTIVES: To develop a liquid chromatography-tandem mass spectrometry （LC-MS/MS） analytical method for the determination of oleandrin in blood and liver tissues, which could be applied to the cases of death caused by oleander poisoning.
Glucose-holmium for radiotherapy: Characterization and in vitro assays.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Dec 21, 2018
BACKGROUND: The existence of saccharide-holmium complexes, containing mono or polysaccharide molecules, is an attractive hypothesis toward a radiation therapy (RT) with beta-emitters targeting high glucose metabolic human sites. To exam such hypothes...
Evaluation of an Artificial Neural Network Retention Index Model for Chemical Structure Identification in Nontargeted Metabolomics.
Analytical chemistry
Oct 24, 2018
Liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) is a major analytical technique used for nontargeted identification of metabolites in biological fluids. Typically, in LC-ESI-MS/MS based database assi...
Combining Desorption Electrospray Ionization Mass Spectrometry Imaging and Machine Learning for Molecular Recognition of Myocardial Infarction.
Analytical chemistry
Sep 25, 2018
Lipid profile changes in heart muscle have been previously linked to cardiac ischemia and myocardial infarction, but the spatial distribution of lipids and metabolites in ischemic heart remains to be fully investigated. We performed desorption electr...
Detection of potential new biomarkers of atherosclerosis by probe electrospray ionization mass spectrometry.
Metabolomics : Official journal of the Metabolomic Society
Feb 27, 2018
INTRODUCTION: Atherosclerotic diseases are the leading cause of death worldwide. Biomarkers of atherosclerosis are required to monitor and prevent disease progression. While mass spectrometry is a promising technique to search for such biomarkers, it...
A simple LC-MS/MS method for determination of deferasirox in human plasma: Troubleshooting of interference from ferric ion in method development and its application.
Journal of pharmaceutical and biomedical analysis
Dec 28, 2017
As an orally active iron chelator, deferasirox forms its ion complexes in the prepared plasma samples and LC-MS mobile phase where ferric ion exists, and then comparing with the nominal concentration level, a lower detected concentration level of def...
Chemical findings and in vitro biological studies to uphold the use of Ficus exasperata Vahl leaf and stem bark.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 27, 2017
Ficus exasperata Vahl, commonly known as sandpaper, is a terrestrial Afro-tropical tree used in popular medicine. Despite the existence of some works on the biological activities of this species, its chemical composition is still poorly known. The ai...
Chromatography, High Pressure Liquid
Spectrometry, Mass, Electrospray Ionization
Plant Stems
Plant Leaves
Drug Screening Assays, Antitumor
Plant Bark
Ficus
Spectrophotometry, Ultraviolet
Functional Food
Inhibitory Concentration 50
Free Radical Scavengers
Superoxides
Cell Line, Tumor
Plant Extracts
Nitric Oxide
Hypoglycemic Agents
Dose-Response Relationship, Drug
Dietary Supplements
Humans
Reproducibility of Results
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