AIMC Topic: Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
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Pre-trained Maldi Transformers improve MALDI-TOF MS-based prediction.
Computers in biology and medicine
Jan 22, 2025
For the last decade, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been the reference method for species identification in clinical microbiology. Hampered by a historical lack of open data, machine le...
Non-Invasive Diagnosis of Moyamoya Disease Using Serum Metabolic Fingerprints and Machine Learning.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Dec 31, 2024
Moyamoya disease (MMD) is a progressive cerebrovascular disorder that increases the risk of intracranial ischemia and hemorrhage. Timely diagnosis and intervention can significantly reduce the risk of new-onset stroke in patients with MMD. However, t...
Analysis of high-molecular-weight proteins using MALDI-TOF MS and machine learning for the differentiation of clinically relevant Clostridioides difficile ribotypes.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Dec 17, 2024
PURPOSE: Clostridioides difficile is the main cause of antibiotic related diarrhea and some ribotypes (RT), such as RT027, RT181 or RT078, are considered high risk clones. A fast and reliable approach for C. difficile ribotyping is needed for a corre...
Mass Spectrometry Imaging for Spatial Ingredient Classification in Plant-Based Food.
Journal of the American Society for Mass Spectrometry
Dec 7, 2024
Mass spectrometry imaging (MSI) techniques enable the generation of molecular maps from complex and heterogeneous matrices. A burger patty, whether plant-based or meat-based, represents one such complex matrix where studying the spatial distribution ...
An antimicrobial drug recommender system using MALDI-TOF MS and dual-branch neural networks.
eLife
Nov 14, 2024
Timely and effective use of antimicrobial drugs can improve patient outcomes, as well as help safeguard against resistance development. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is currently routinely...
Pioneering Klebsiella Pneumoniae Antibiotic Resistance Prediction With Artificial Intelligence-Clinical Decision Support System-Enhanced Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: Retrospective Study.
Journal of medical Internet research
Nov 7, 2024
BACKGROUND: The rising prevalence and swift spread of multidrug-resistant gram-negative bacteria (MDR-GNB), especially Klebsiella pneumoniae (KP), present a critical global health threat highlighted by the World Health Organization, with mortality ra...
Discriminating fingerprints of chronic neuropathic pain following spinal cord injury using artificial neural networks and mass spectrometry analysis of female mice serum.
Neurochemistry international
Oct 23, 2024
Spinal cord injury (SCI) often leads to central neuropathic pain, a condition associated with significant morbidity and is challenging in terms of the clinical management. Despite extensive efforts, identifying effective biomarkers for neuropathic pa...
Diagnostic performance of an automated robot for MALDI target preparation in microbial identification.
Journal of clinical microbiology
Sep 19, 2024
The MBT Pathfinder is an automated colony-picking robot designed for efficient sample preparation in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. This article presents results from three key experiments ev...
Artificial intelligence-clinical decision support system for enhanced infectious disease management: Accelerating ceftazidime-avibactam resistance detection in Klebsiella pneumoniae.
Journal of infection and public health
Sep 10, 2024
BACKGROUND: Effective and rapid diagnostic strategies are required to manage antibiotic resistance in Klebsiella pneumonia (KP). This study aimed to design an artificial intelligence-clinical decision support system (AI-CDSS) using matrix-assisted la...
Decision Support Systems, Clinical
Klebsiella pneumoniae
Klebsiella Infections
Microbial Sensitivity Tests
Drug Resistance, Multiple, Bacterial
Humans
Ceftazidime
Artificial Intelligence
Machine Learning
Anti-Bacterial Agents
Drug Combinations
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Azabicyclo Compounds
Accurate prediction of antimicrobial resistance and genetic marker of Staphylococcus aureus clinical isolates using MALDI-TOF MS and machine learning - across DRIAMS and Taiwan database.
International journal of antimicrobial agents
Sep 6, 2024
BACKGROUND: The use of matrix-assisted laser desorption/ionisation-time-of-flight mass spectra (MALDI-TOF MS) with machine learning (ML) has been explored for predicting antimicrobial resistance. This study evaluates the effectiveness of MALDI-TOF MS...
Taiwan
Bacterial Proteins
Genetic Markers
Staphylococcal Infections
Humans
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Oxacillin
Machine Learning
Databases, Factual
Anti-Bacterial Agents
Penicillin-Binding Proteins
Microbial Sensitivity Tests
Drug Resistance, Bacterial
Staphylococcus aureus
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