Analytical methods : advancing methods and applications
Aug 21, 2025
Dry eye disease (DED) and depression exhibit high comorbidity, yet lipid and purine diagnostic biomarkers for depression-related DED remain unidentified. In this study, matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI)...
This study aimed to investigate the potential of peptide mass fingerprints (PMFs) of the serum peptidome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), in combination with machine learning algorithm...
BACKGROUND: Clostridioides difficile is a major cause of hospital-acquired diarrhea and a driver of nosocomial outbreaks, yet rapid, accurate ribotype identification remains challenging. We sought to develop a MALDI-TOF MS-based workflow coupled with...
Methicillin-resistant (MRSA) is a major cause of healthcare-associated infections including bacteremia. The rapid detection of MRSA is essential for prompt treatment and improved outcomes. However, traditional MRSA screening and confirmatory tests b...
Accurate identification of Vibrio harveyi clade species is critical for seafood safety and the control of aquaculture diseases. However, existing methods demonstrate limited classification performance. This study presents an artificial intelligence-a...
The detection of mixed-species bacterial samples plays a vital role in ensuring food safety, yet research in this area remains notably limited. This study investigates the integration of MALDI-TOF MS-derived peptidome profiles with artificial intelli...
Antibiotic resistance in Burkholderia pseudomallei (Bp) is a growing public health concern requiring urgent attention. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has emerged as a rapid bacterial identi...
UNLABELLED: serotyping is essential for epidemiological studies and clinical treatment guidance. However, traditional serological agglutination methods are time-consuming, technically complex, and difficult to adopt at scale. Matrix-assisted laser d...
Tissue atlases provide foundational knowledge on the cellular organization and molecular distributions across molecular classes and spatial scales. Here, we construct a comprehensive spatiomolecular lipid atlas of the human kidney from 29 donor tissu...
Laser desorption ionization mass spectrometry (LDI-MS) is a critical platform for high-throughput nontargeted metabolomics analysis in clinical diagnosis. However, traditional organic matrices inherently suffer from background interference in the low...
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