Wearable sensors allow non-invasive monitoring of sweat metabolites, but their reliance on molecular recognition elements limits both physiological coverage and temporal resolution. Here we report an all-flexible chronoepifluidic surface-enhanced Ram...
Analytical methods : advancing methods and applications
Aug 21, 2025
Developing a convenient, accurate, and cost-effective analytical method for the detection of Cytochrome P450 (CYP) mediated drug bioactivation remains a challenge. The present study proposes a method using Raman spectroscopy (RS) combined with machin...
SERS has revolutionized viral detection with its high sensitivity and specificity. This review comprehensively explores the application progress, challenges, and future directions of SERS in viral detection. Firstly, the fundamental principles of SER...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 15, 2025
Vascular aging-related remodeling is a common pathological basis for many chronic diseases, so early detection of physical arterial aging is important for their prevention and control. Existing staining methods can only analyze a limited number of ti...
Whole-cell biosensors (WCBs), which detect targeting analytes through cellular responses, have become powerful tools for environmental monitoring. However, existing WCBs often rely on the single-channel low-dimension signal outputs (e.g., fluorescenc...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 13, 2025
Type 2 diabetes mellitus (T2DM) is associated with increased skeletal fragility, yet standard clinical assessments often fail to detect diabetes-induced changes in bone quality. Raman spectroscopy (RS), a label-free and non-destructive technique, off...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Aug 9, 2025
Colorectal cancer remains a major health burden, and its early detection is crucial for effective treatment. This study investigates the use of a handheld Raman spectrometer in combination with machine learning to classify colorectal tissue samples c...
The journal of physical chemistry letters
Aug 8, 2025
Single-molecule detection of post-translational modifications (PTMs) such as phosphorylation plays a crucial role in early diagnosis of diseases and therapeutics development. Although single-molecule surface-enhanced Raman spectroscopy (SM-SERS) dete...
Raman spectroscopy is a key technology for to ensure sustainable and efficient food safety practices owing to its non-invasive and sensitive molecular analysis. This review highlights the recent advancements in Raman-based techniques, which offer imp...
Alkaline phosphatase (ALP) is a clinically important hydrolase enzyme and a valuable biomarker for hepatobiliary diseases, metabolic bone disorders, and certain malignancies. Raman-based miniaturized sensors, particularly those employing surface-enha...
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