BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for improving the motor symptoms of advanced Parkinson's disease (PD). Accurate positioning of the stimulation electrodes is necessary for better clin...
The identification of oscillatory neural markers of Parkinson's disease (PD) can contribute not only to the understanding of functional mechanisms of the disorder, but may also serve in adaptive deep brain stimulation (DBS) systems. These systems see...
BACKGROUND: Recognition of human behavioral activities using local field potential (LFP) signals recorded from the Subthalamic Nuclei (STN) has applications in developing the next generation of deep brain stimulation (DBS) systems. DBS therapy is oft...
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Nov 5, 2019
OBJECTIVE: Accurate and reliable detection of tremor onset in Parkinson's disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy. Here, we investigated the potential use of feature engineering and machine learning m...
OBJECTIVE: The identification of functional regions, in particular the subthalamic nucleus, through microelectrode recording (MER) is the key step in deep brain stimulation (DBS). To eliminate variability in a neurosurgeon's judgment, this study pres...
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has shown clinical potential for relieving the motor symptoms of advanced Parkinson's disease. While accurate localization of the STN is critical for consistent across-patients effective D...
BACKGROUND: Classification of human behavior from brain signals has potential application in developing closed-loop deep brain stimulation (DBS) systems. This paper presents a human behavior classification using local field potential (LFP) signals re...
Neural networks : the official journal of the International Neural Network Society
Jul 26, 2017
Modeling and implementation of the nonlinear neural system with physiologically plausible dynamic behaviors are considerably meaningful in the field of computational neuroscience. This study introduces a novel hardware platform to investigate the dyn...
Movement disorders : official journal of the Movement Disorder Society
Oct 6, 2016
BACKGROUND: Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery for Parkinson's disease. Usually, the demarcation of the S...
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Sep 13, 2016
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to ...
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