AIMC Topic: Subthalamic Nucleus
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Improved detection of Parkinsonian resting tremor with feature engineering and Kalman filtering.
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
Nov 5, 2019
OBJECTIVE: Accurate and reliable detection of tremor onset in Parkinson's disease (PD) is critical to the success of adaptive deep brain stimulation (aDBS) therapy. Here, we investigated the potential use of feature engineering and machine learning m...
Online identification of functional regions in deep brain stimulation based on an unsupervised random forest with feature selection.
Journal of neural engineering
Oct 23, 2019
OBJECTIVE: The identification of functional regions, in particular the subthalamic nucleus, through microelectrode recording (MER) is the key step in deep brain stimulation (DBS). To eliminate variability in a neurosurgeon's judgment, this study pres...
Automatic localization of the subthalamic nucleus on patient-specific clinical MRI by incorporating 7 T MRI and machine learning: Application in deep brain stimulation.
Human brain mapping
Oct 31, 2018
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has shown clinical potential for relieving the motor symptoms of advanced Parkinson's disease. While accurate localization of the STN is critical for consistent across-patients effective D...
A hierarchical structure for human behavior classification using STN local field potentials.
Journal of neuroscience methods
Oct 7, 2017
BACKGROUND: Classification of human behavior from brain signals has potential application in developing closed-loop deep brain stimulation (DBS) systems. This paper presents a human behavior classification using local field potential (LFP) signals re...
Efficient hardware implementation of the subthalamic nucleus-external globus pallidus oscillation system and its dynamics investigation.
Neural networks : the official journal of the International Neural Network Society
Jul 26, 2017
Modeling and implementation of the nonlinear neural system with physiologically plausible dynamic behaviors are considerably meaningful in the field of computational neuroscience. This study introduces a novel hardware platform to investigate the dyn...
Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery.
Movement disorders : official journal of the Movement Disorder Society
Oct 6, 2016
BACKGROUND: Microelectrode recordings along preplanned trajectories are often used for accurate definition of the subthalamic nucleus (STN) borders during deep brain stimulation (DBS) surgery for Parkinson's disease. Usually, the demarcation of the S...
Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Sep 13, 2016
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to ...
A Fuzzy Inference System for Closed-Loop Deep Brain Stimulation in Parkinson's Disease.
Journal of medical systems
Sep 18, 2015
Parkinsons disease is a complex neurodegenerative disorder for which patients present many symptoms, tremor being the main one. In advanced stages of the disease, Deep Brain Stimulation is a generalized therapy which can significantly improve the mot...
Machine Learning Approach to Optimizing Combined Stimulation and Medication Therapies for Parkinson's Disease.
Brain stimulation
Jun 15, 2015
BACKGROUND: Deep brain stimulation (DBS) of the subthalamic region is an established therapy for advanced Parkinson's disease (PD). However, patients often require time-intensive post-operative management to balance their coupled stimulation and medi...
AI-DBS study: protocol for a longitudinal prospective observational cohort study of patients with Parkinson's disease for the development of neuronal fingerprints using artificial intelligence.
BMJ open
May 16, 2025
INTRODUCTION: Deep brain stimulation (DBS) is a proven effective treatment for Parkinson's disease (PD). However, titrating DBS stimulation parameters is a labourious process and requires frequent hospital visits. Additionally, its current applicatio...
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