Combinatorial chemistry & high throughput screening
Jan 1, 2020
BACKGROUND: Evidence have increasingly indicated that for human disease, cell metabolism are deeply associated with proteins. Structural mutations and dysregulations of these proteins contribute to the development of the complex disease. Free radical...
INTRODUCTION: The research and development of drugs, related to the central nervous system (CNS) diseases is a long and arduous process with high cost, long cycle and low success rate. Identification of key features based on available CNS drugs is of...
Artificial intelligence and deep learning are areas of high interest for radiology investigators at present. However, the field of machine learning encompasses multiple statistics-based techniques useful for investigators, which may be complementary ...
Journal of the American Medical Informatics Association : JAMIA
Jan 1, 2020
OBJECTIVE: We implement 2 different multitask learning (MTL) techniques, hard parameter sharing and cross-stitch, to train a word-level convolutional neural network (CNN) specifically designed for automatic extraction of cancer data from unstructured...
BACKGROUND: Technology-based objective measures (TOMs) recently gained relevance to support clinicians in the assessment of motor function in Parkinson's disease (PD), although limited data are available in the early phases.
Journal of the American Medical Informatics Association : JAMIA
Jan 1, 2020
OBJECTIVE: This article summarizes the preparation, organization, evaluation, and results of Track 2 of the 2018 National NLP Clinical Challenges shared task. Track 2 focused on extraction of adverse drug events (ADEs) from clinical records and evalu...
Massive generation of health-related data has been key in enabling the big data science initiative to gain new insights in healthcare. Nursing can benefit from this era of big data science, as there is a growing need for new discoveries from large qu...
Medicinal chemistry (Shariqah (United Arab Emirates))
Jan 1, 2020
BACKGROUND: Tuberculosis is one of the biggest threats to human health. Recent studies have demonstrated that anti-tubercular peptides are promising candidates for the discovery of new anti-tubercular drugs. Since experimental methods are still labor...
Technology and health care : official journal of the European Society for Engineering and Medicine
Jan 1, 2020
BACKGROUND: Periodontitis (PD), a form of gum disease, is a major public health concern as it is globally prevalent and harms both individual quality of life and economic productivity. Global cost in lost productivity is estimated at US$54 billion an...
MOTIVATION: Classification of protein sequences is one big task in bioinformatics and has many applications. Different machine learning methods exist and are applied on these problems, such as support vector machines (SVM), random forests (RF) and ne...
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