AIMC Topic: Survival Analysis

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The prognostic impact of the tumour stroma fraction: A machine learning-based analysis in 16 human solid tumour types.

EBioMedicine
BACKGROUND: The development of a reactive tumour stroma is a hallmark of tumour progression and pronounced tumour stroma is generally considered to be associated with clinical aggressiveness. The variability between tumour types regarding stroma frac...

Development of machine learning model algorithm for prediction of 5-year soft tissue myxoid liposarcoma survival.

Journal of surgical oncology
BACKGROUND: Predicting survival in myxoid liposarcoma (MLS) patients is very challenging given its propensity to metastasize and the controversial role of adjuvant therapy. The purpose of this study was to develop a machine-learning algorithm for the...

Artificial intelligence prediction model for overall survival of clear cell renal cell carcinoma based on a 21-gene molecular prognostic score system.

Aging
We developed and validated a new prognostic model for predicting the overall survival in clear cell renal cell carcinoma (ccRCC) patients. In this study, artificial intelligence (AI) algorithms including random forest and neural network were trained ...

Using Automated Machine Learning to Predict the Mortality of Patients With COVID-19: Prediction Model Development Study.

Journal of medical Internet research
BACKGROUND: During a pandemic, it is important for clinicians to stratify patients and decide who receives limited medical resources. Machine learning models have been proposed to accurately predict COVID-19 disease severity. Previous studies have ty...

CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre-B-cell acute lymphoblastic leukaemia.

British journal of haematology
Disease relapse is the greatest cause of treatment failure in paediatric B-cell acute lymphoblastic leukaemia (B-ALL). Current risk stratifications fail to capture all patients at risk of relapse. Herein, we used a machine-learning approach to identi...

Deep Neural Networks Can Predict New-Onset Atrial Fibrillation From the 12-Lead ECG and Help Identify Those at Risk of Atrial Fibrillation-Related Stroke.

Circulation
BACKGROUND: Atrial fibrillation (AF) is associated with substantial morbidity, especially when it goes undetected. If new-onset AF could be predicted, targeted screening could be used to find it early. We hypothesized that a deep neural network could...

Deep-learning-assisted analysis of echocardiographic videos improves predictions of all-cause mortality.

Nature biomedical engineering
Machine learning promises to assist physicians with predictions of mortality and of other future clinical events by learning complex patterns from historical data, such as longitudinal electronic health records. Here we show that a convolutional neur...

Investigating the relevance of major signaling pathways in cancer survival using a biologically meaningful deep learning model.

BMC bioinformatics
BACKGROUND: Survival analysis is an important part of cancer studies. In addition to the existing Cox proportional hazards model, deep learning models have recently been proposed in survival prediction, which directly integrates multi-omics data of a...

Application of a novel machine learning framework for predicting non-metastatic prostate cancer-specific mortality in men using the Surveillance, Epidemiology, and End Results (SEER) database.

The Lancet. Digital health
BACKGROUND: Accurate prognostication is crucial in treatment decisions made for men diagnosed with non-metastatic prostate cancer. Current models rely on prespecified variables, which limits their performance. We aimed to investigate a novel machine ...

DeepCompete : A deep learning approach to competing risks in continuous time domain.

AMIA ... Annual Symposium proceedings. AMIA Symposium
An increasing number of people survive longer ages leading to a growing population of people 65 years of age or older. A large percentage of this population is afflicted with multiple acute diseases (multi-morbidity). Clinicians need new tools to qua...