AIMC Topic: Tissue Plasminogen Activator
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Radiomics-Based Intracranial Thrombus Features on CT and CTA Predict Recanalization with Intravenous Alteplase in Patients with Acute Ischemic Stroke.
AJNR. American journal of neuroradiology
Dec 20, 2018
BACKGROUND AND PURPOSE: Thrombus characteristics identified on non-contrast CT (NCCT) are potentially associated with recanalization with intravenous (IV) alteplase in patients with acute ischemic stroke (AIS). Our aim was to determine the best radio...
Machine learning methods for leveraging baseline covariate information to improve the efficiency of clinical trials.
Statistics in medicine
Nov 25, 2018
Clinical trials are widely considered the gold standard for treatment evaluation, and they can be highly expensive in terms of time and money. The efficiency of clinical trials can be improved by incorporating information from baseline covariates tha...
Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning.
Stroke
May 2, 2018
BACKGROUND AND PURPOSE: Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to d...
Spontaneous Intraventricular Hemorrhage: When Should Intraventricular tPA Be Considered?
Seminars in respiratory and critical care medicine
Dec 20, 2017
Spontaneous intracerebral hemorrhage (ICH) is the most common cause of intraventricular hemorrhage (IVH) in adults. Complicating approximately 40% of ICH cases, IVH adds to the morbidity and mortality of this often fatal form of stroke. It is also a ...
Pneumatic Displacement of Submacular Hemorrhage with Subretinal Air and Tissue Plasminogen Activator: Initial United States Experience.
Ophthalmology. Retina
Sep 28, 2017
PURPOSE: To present the initial multicenter experience of using subretinal air injection in combination with tissue plasminogen activator (tPA) at the time of pars plana vitrectomy (PPV) to displace submacular hemorrhage (SMH).
Visual Acuity
Fibrinolytic Agents
Humans
Injections, Intraocular
Tomography, Optical Coherence
Retrospective Studies
Retinal Hemorrhage
Fundus Oculi
Female
Vitrectomy
Time Factors
Retina
Aged
Tissue Plasminogen Activator
United States
Aged, 80 and over
Air
Male
Treatment Outcome
Endotamponade
Middle Aged
Follow-Up Studies
Fluorescein Angiography
Prediction of final infarct volume on subacute MRI by quantifying cerebral edema in ischemic stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Jan 1, 2016
Final infarct volume in stroke trials is assessed on images obtained between 30 and 90 days after stroke onset. Imaging at such delayed timepoints is problematic because patients may be lost to follow-up or die before the scan. Obtaining an early ass...
Development of a deep neural network model for ultra-early neurological deterioration in ischemic stroke and analysis of associated risk factors.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Jun 1, 2025
BACKGROUND: In this study, we established a deep neural network (DNN)-based predictive model, aiming to provide a basis for improving the treatment prognosis of early neurological deterioration (END) in patients with ultra-early ischemic stroke after...
Machine Learning Model Predictors of Intrapleural Tissue Plasminogen Activator and DNase Failure in Pleural Infection: A Multicenter Study.
Annals of the American Thoracic Society
Feb 1, 2025
Intrapleural enzyme therapy (IET) with tissue plasminogen activator (tPA) and DNase has been shown to reduce the need for surgical intervention for complicated parapneumonic effusion/empyema (CPPE/empyema). Failure of IET may lead to delayed care an...
Correlation between Immune-Inflammatory Markers and Clinical Features in Patients with Acute Ischemic Stroke.
Acta neurologica Taiwanica
Dec 1, 2020
OBJECTIVE: Chronic inflammatory processes involving the vascular wall may induce atherosclerosis. Immune-inflammatory processes proceed throughout all stages of acute stroke. We investigated the association of three immune-inflammatory markers, namel...
Efficacy and Safety Evaluation on Arterial Thrombolysis in Treating Acute Cerebral Infarction.
Cell biochemistry and biophysics
Nov 1, 2015
The objective of this study was to evaluate the efficacy and safety of intra-arterial thrombolysis in treating acute cerebral infarction and further discuss the indications of acute cerebral infarction treatment, in order to enhance the therapeutic e...
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