AIMC Topic: Vascular Endothelial Growth Factor Receptor-2

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Application of deep learning algorithm for judicious use of anti-VEGF in diabetic macular edema.

Scientific reports Feb 7, 2025
Diabetic Macular Edema (DME) is a major complication of diabetic retinopathy characterized by fluid accumulation in the macula, leading to vision impairment. The standard treatment involves anti-VEGF (Vascular Endothelial Growth Factor) therapy, but ...
Middle Aged Deep Learning Aged Male Macular Edema Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2 Humans Angiogenesis Inhibitors Diabetic Retinopathy Tomography, Optical Coherence Algorithms Neural Networks, Computer Female
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Molecular docking aided machine learning for the identification of potential VEGFR inhibitors against renal cell carcinoma.

Medical oncology (Northwood, London, England) Jul 9, 2024
Renal cell carcinoma is a highly vascular tumor associated with vascular endothelial growth factor (VEGF) expression. The Vascular Endothelial Growth Factor -2 (VEGF-2) and its receptor was identified as a potential anti-cancer target, and it plays a...
Humans Antineoplastic Agents Drug Repositioning Molecular Dynamics Simulation Machine Learning Molecular Docking Simulation Protein Kinase Inhibitors Carcinoma, Renal Cell Vascular Endothelial Growth Factor Receptor-2 Kidney Neoplasms
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From Deep Learning to the Discovery of Promising VEGFR-2 Inhibitors.

ChemMedChem Jun 20, 2024
Vascular endothelial growth factor receptor 2 (VEGFR-2) stands as a prominent therapeutic target in oncology, playing a critical role in angiogenesis, tumor growth, and metastasis. FDA-approved VEGFR-2 inhibitors are associated with diverse side effe...
Protein Kinase Inhibitors Molecular Structure Vascular Endothelial Growth Factor Receptor-2 Cell Line, Tumor Cell Proliferation Drug Screening Assays, Antitumor Structure-Activity Relationship Dose-Response Relationship, Drug Antineoplastic Agents Deep Learning Humans Molecular Docking Simulation Drug Discovery
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Potential inhibitors of VEGFR1, VEGFR2, and VEGFR3 developed through Deep Learning for the treatment of Cervical Cancer.

Scientific reports Jun 10, 2024
Cervical cancer stands as a prevalent gynaecologic malignancy affecting women globally, often linked to persistent human papillomavirus infection. Biomarkers associated with cervical cancer, including VEGF-A, VEGF-B, VEGF-C, VEGF-D, and VEGF-E, show ...
Humans Vascular Endothelial Growth Factor Receptor-2 Vascular Endothelial Growth Factor Receptor-1 Vascular Endothelial Growth Factor Receptor-3 Protein Kinase Inhibitors Female Molecular Docking Simulation Uterine Cervical Neoplasms Deep Learning
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Chemical Space Mimicry for Drug Discovery.

Journal of chemical information and modeling Apr 3, 2017
We describe a new library generation method, Machine-based Identification of Molecules Inside Characterized Space (MIMICS), that generates sets of molecules inspired by a text-based input. MIMICS-generated libraries were found to preserve distributio...
Neural Networks, Computer Vascular Endothelial Growth Factor Receptor-2 Drug Discovery
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Investigating the anti-angiogenic effects of Fufang Kushen Injection in combination with cisplatin using a zebrafish model.

Pakistan journal of pharmaceutical sciences Sep 1, 2020
The Traditional Chinese Medicine formula Fufang Kushen Injection (FKI) has demonstrated potential to enhance the efficacy and reduce the toxicity of the chemotherapeutic drug cisplatin. However, there is insufficient evidence to determine whether the...
Zebrafish Proteins Cisplatin Animals, Genetically Modified Dose-Response Relationship, Drug Vascular Endothelial Growth Factor Receptor-2 Drugs, Chinese Herbal Animals Neovascularization, Physiologic Zebrafish Angiogenesis Inhibitors Drug Synergism
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Marsdeniae tenacissimae extract (MTE) suppresses cell proliferation by attenuating VEGF/VEGFR2 interactions and promotes apoptosis through regulating PKC pathway in human umbilical vein endothelial cells.

Chinese journal of natural medicines Dec 1, 2016
Marsdeniae tenacissimae extract (MTE), commonly known as Xiao-Ai-Ping in China, is a traditional Chinese herb medicine capable of inhibiting proliferation and metastasis and boosting apoptosis in various cancer cells. However, little is known about t...
Protein Kinase C Signal Transduction Cell Cycle Plant Extracts Apoptosis Marsdenia Humans Cell Proliferation Human Umbilical Vein Endothelial Cells Vascular Endothelial Growth Factor A Vascular Endothelial Growth Factor Receptor-2
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