AIMC Topic: Virus Diseases

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A generalizable 29-mRNA neural-network classifier for acute bacterial and viral infections.

Nature communications
Improved identification of bacterial and viral infections would reduce morbidity from sepsis, reduce antibiotic overuse, and lower healthcare costs. Here, we develop a generalizable host-gene-expression-based classifier for acute bacterial and viral ...

Machine learning in the clinical microbiology laboratory: has the time come for routine practice?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
BACKGROUND: Machine learning (ML) allows the analysis of complex and large data sets and has the potential to improve health care. The clinical microbiology laboratory, at the interface of clinical practice and diagnostics, is of special interest for...

Controlling testing volume for respiratory viruses using machine learning and text mining.

AMIA ... Annual Symposium proceedings. AMIA Symposium
Viral testing for pediatric inpatients with respiratory symptoms is common, with considerable associated charges. In an attempt to reduce testing volumes, we studied whether data available at the time of admission could aid in identifying children wi...

Augmentation of Infrared Microscopy of White Blood Cells and Medical Measures for Rapid and Accurate Diagnosis of Bacterial or Viral Infections in Febrile Pediatric Oncology Patients: An Expert System-Based Study.

Analytical chemistry
Infectious diseases, a major contributor to high mortality rates, often exhibit similar symptoms, despite variations in immune responses to bacterial or viral infections. Rapidly differentiating bacterial infections from viral infections in febrile p...

Robust Diagnosis of Acute Bacterial and Viral Infections via Host Gene Expression Rank-Based Ensemble Machine Learning Algorithm: A Multi-Cohort Model Development and Validation Study.

Clinical chemistry
BACKGROUND: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting ...

HervD Atlas: a curated knowledgebase of associations between human endogenous retroviruses and diseases.

Nucleic acids research
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been condu...

Current status and future perspectives of computational studies on human-virus protein-protein interactions.

Briefings in bioinformatics
The protein-protein interactions (PPIs) between human and viruses mediate viral infection and host immunity processes. Therefore, the study of human-virus PPIs can help us understand the principles of human-virus relationships and can thus guide the ...

Towards development of a novel universal medical diagnostic method: Raman spectroscopy and machine learning.

Chemical Society reviews
Many problems exist within the myriad of currently employed screening and diagnostic methods. Further, an incredibly wide variety of procedures are used to identify an even greater number of diseases which exist in the world. There is a definite unme...

Lyapunov functional for virus infection model with diffusion and state-dependent delays.

Mathematical biosciences and engineering : MBE
In this paper, a virus dynamics model with diffusion, state-dependent delays and a general nonlinear functional response is investigated. At first, the dynamical system is constructed on a nonlinear metric space. Then the stability of the interior eq...