Improved identification of bacterial and viral infections would reduce morbidity from sepsis, reduce antibiotic overuse, and lower healthcare costs. Here, we develop a generalizable host-gene-expression-based classifier for acute bacterial and viral ...
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Feb 12, 2020
BACKGROUND: Machine learning (ML) allows the analysis of complex and large data sets and has the potential to improve health care. The clinical microbiology laboratory, at the interface of clinical practice and diagnostics, is of special interest for...
AMIA ... Annual Symposium proceedings. AMIA Symposium
Feb 10, 2017
Viral testing for pediatric inpatients with respiratory symptoms is common, with considerable associated charges. In an attempt to reduce testing volumes, we studied whether data available at the time of admission could aid in identifying children wi...
Infectious diseases, a major contributor to high mortality rates, often exhibit similar symptoms, despite variations in immune responses to bacterial or viral infections. Rapidly differentiating bacterial infections from viral infections in febrile p...
BACKGROUND: The accurate and prompt diagnosis of infections is essential for improving patient outcomes and preventing bacterial drug resistance. Host gene expression profiling as an approach to infection diagnosis holds great potential in assisting ...
Human endogenous retroviruses (HERVs), as remnants of ancient exogenous retrovirus infected and integrated into germ cells, comprise ∼8% of the human genome. These HERVs have been implicated in numerous diseases, and extensive research has been condu...
The protein-protein interactions (PPIs) between human and viruses mediate viral infection and host immunity processes. Therefore, the study of human-virus PPIs can help us understand the principles of human-virus relationships and can thus guide the ...
Many problems exist within the myriad of currently employed screening and diagnostic methods. Further, an incredibly wide variety of procedures are used to identify an even greater number of diseases which exist in the world. There is a definite unme...
Mathematical biosciences and engineering : MBE
Jan 29, 2019
In this paper, a virus dynamics model with diffusion, state-dependent delays and a general nonlinear functional response is investigated. At first, the dynamical system is constructed on a nonlinear metric space. Then the stability of the interior eq...
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