AIMC Topic: White Matter

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On the application of hybrid deep 3D convolutional neural network algorithms for predicting the micromechanics of brain white matter.

Computer methods and programs in biomedicine
BACKGROUND: Material characterization of brain white matter (BWM) is difficult due to the anisotropy inherent to the three-dimensional microstructure and the various interactions between heterogeneous brain-tissue (axon, myelin, and glia). Developing...

Machine learning quantification of Amyloid-β deposits in the temporal lobe of 131 brain bank cases.

Acta neuropathologica communications
Accurate and scalable quantification of amyloid-β (Aβ) pathology is crucial for deeper disease phenotyping and furthering research in Alzheimer Disease (AD). This multidisciplinary study addresses the current limitations on neuropathology by leveragi...

Improved Dementia Prediction in Cerebral Small Vessel Disease Using Deep Learning-Derived Diffusion Scalar Maps From T1.

Stroke
BACKGROUND: Cerebral small vessel disease is the most common pathology underlying vascular dementia. In small vessel disease, diffusion tensor imaging is more sensitive to white matter damage and better predicts dementia risk than conventional magnet...

Development and validation of a two-stage convolutional neural network algorithm for segmentation of MRI white matter hyperintensities for longitudinal studies in CADASIL.

Computers in biology and medicine
BACKGROUND: Segmentation of white matter hyperintensities (WMH) in CADASIL, one of the most severe cerebral small vessel disease of genetic origin, is challenging.

Evolution of white matter hyperintensity segmentation methods and implementation over the past two decades; an incomplete shift towards deep learning.

Brain imaging and behavior
This systematic review examines the prevalence, underlying mechanisms, cohort characteristics, evaluation criteria, and cohort types in white matter hyperintensity (WMH) pipeline and implementation literature spanning the last two decades. Following ...

Detection of diffusely abnormal white matter in multiple sclerosis on multiparametric brain MRI using semi-supervised deep learning.

Scientific reports
In addition to focal lesions, diffusely abnormal white matter (DAWM) is seen on brain MRI of multiple sclerosis (MS) patients and may represent early or distinct disease processes. The role of MRI-observed DAWM is understudied due to a lack of automa...

Machine-learning-based feature selection to identify attention-deficit hyperactivity disorder using whole-brain white matter microstructure: A longitudinal study.

Asian journal of psychiatry
BACKGROUND: We aimed to identify important features of white matter microstructures collectively distinguishing individuals with attention-deficit/hyperactivity disorder (ADHD) from those without ADHD using a machine-learning approach.

Deep learning with diffusion MRI as in vivo microscope reveals sex-related differences in human white matter microstructure.

Scientific reports
Biological sex is a crucial variable in neuroscience studies where sex differences have been documented across cognitive functions and neuropsychiatric disorders. While gross statistical differences have been previously documented in macroscopic brai...

Artificial intelligence for volumetric measurement of cerebral white matter hyperintensities on thick-slice fluid-attenuated inversion recovery (FLAIR) magnetic resonance images from multiple centers.

Scientific reports
We aimed to develop a new artificial intelligence software that can automatically extract and measure the volume of white matter hyperintensities (WMHs) in head magnetic resonance imaging (MRI) using only thick-slice fluid-attenuated inversion recove...